A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ

Many natural-product like drugs have a tetracyclic terpenoid core. Here, the authors developed a synthesis of triterpene-like tetracyclic systems, and apply this method to the preparation of a number of enantiomeric compounds, two of which are very selective ligands for estrogen receptor beta

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Autores principales:	Wan Shin Kim, Zachary A. Shalit, Sidney M. Nguyen, Emmalie Schoepke, Alan Eastman, Thomas P. Burris, Arti B. Gaur, Glenn C. Micalizio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e48d05268db34d77806be736c82cc8ae
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spelling	oai:doaj.org-article:e48d05268db34d77806be736c82cc8ae2021-12-02T16:57:21ZA synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ10.1038/s41467-019-10415-62041-1723https://doaj.org/article/e48d05268db34d77806be736c82cc8ae2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10415-6https://doaj.org/toc/2041-1723Many natural-product like drugs have a tetracyclic terpenoid core. Here, the authors developed a synthesis of triterpene-like tetracyclic systems, and apply this method to the preparation of a number of enantiomeric compounds, two of which are very selective ligands for estrogen receptor betaWan Shin KimZachary A. ShalitSidney M. NguyenEmmalie SchoepkeAlan EastmanThomas P. BurrisArti B. GaurGlenn C. MicalizioNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wan Shin Kim Zachary A. Shalit Sidney M. Nguyen Emmalie Schoepke Alan Eastman Thomas P. Burris Arti B. Gaur Glenn C. Micalizio A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ
description	Many natural-product like drugs have a tetracyclic terpenoid core. Here, the authors developed a synthesis of triterpene-like tetracyclic systems, and apply this method to the preparation of a number of enantiomeric compounds, two of which are very selective ligands for estrogen receptor beta
format	article
author	Wan Shin Kim Zachary A. Shalit Sidney M. Nguyen Emmalie Schoepke Alan Eastman Thomas P. Burris Arti B. Gaur Glenn C. Micalizio
author_facet	Wan Shin Kim Zachary A. Shalit Sidney M. Nguyen Emmalie Schoepke Alan Eastman Thomas P. Burris Arti B. Gaur Glenn C. Micalizio
author_sort	Wan Shin Kim
title	A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ
title_short	A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ
title_full	A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ
title_fullStr	A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ
title_full_unstemmed	A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ
title_sort	synthesis strategy for tetracyclic terpenoids leads to agonists of erβ
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e48d05268db34d77806be736c82cc8ae
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A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ

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