Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.

<h4>Background</h4>Genome-wide studies have shown that polymorphisms on chromosome 4q25, 16q22 and 1q21 correlate with atrial fibrillation (AF). However, the distribution of these polymorphisms differs significantly among populations.<h4>Objective</h4>To test the polymorphism...

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Autores principales:	Marek Kiliszek, Maria Franaszczyk, Edward Kozluk, Piotr Lodzinski, Agnieszka Piatkowska, Grażyna Broda, Rafal Ploski, Grzegorz Opolski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e490e2cfe8bc4a078e83efe7039baf6f
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spelling	oai:doaj.org-article:e490e2cfe8bc4a078e83efe7039baf6f2021-11-18T06:50:33ZAssociation between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.1932-620310.1371/journal.pone.0021790https://doaj.org/article/e490e2cfe8bc4a078e83efe7039baf6f2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21760908/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Genome-wide studies have shown that polymorphisms on chromosome 4q25, 16q22 and 1q21 correlate with atrial fibrillation (AF). However, the distribution of these polymorphisms differs significantly among populations.<h4>Objective</h4>To test the polymorphisms on chromosome 4q25, 16q22 and 1q21 in a group of patients (pts) that underwent catheter ablation of AF.<h4>Methods</h4>Four hundred and ten patients with AF that underwent pulmonary vein isolation were included in the study. Control group (n = 550) was taken from healthy population, matched for age, sex and presence of hypertension. All participants were genotyped for the presence of the rs2200733, rs10033464, rs17570669, rs3853445, rs6838973 (4q25), rs7193343 (16q22) and rs13376333 (1q21) polymorphisms.<h4>Results</h4>All the polymorphisms tested (except rs17570669) correlated significantly with AF in univariate analysis (p values between 0.039 for rs7193343 and 2.7e-27 for rs2200733), with the odds ratio (OR) 0.572 and 0.617 for rs3853445 and rs6838973, respectively (protective role) and OR 1.268 to 3.52 for the other polymorphisms. All 4q25 SNPs tested but rs3853445 were independently linked with AF in multivariate logistic regression analysis. In haplotype analysis six out of nine 4q25 haplotypes were significantly linked with AF. The T allele of rs2200733 favoured increased number of episodes of AF per month (p = 0.045) and larger pulmonary vein diameter (recessive model, p = 0.032).<h4>Conclusions</h4>Patients qualified for catheter ablation of AF have a significantly higher frequency of 4q25, 16q22 and 1q21 variants than the control group. The T allele of rs2200733 favours larger pulmonary veins and increased number of episodes of AF.Marek KiliszekMaria FranaszczykEdward KozlukPiotr LodzinskiAgnieszka PiatkowskaGrażyna BrodaRafal PloskiGrzegorz OpolskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21790 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marek Kiliszek Maria Franaszczyk Edward Kozluk Piotr Lodzinski Agnieszka Piatkowska Grażyna Broda Rafal Ploski Grzegorz Opolski Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.
description	<h4>Background</h4>Genome-wide studies have shown that polymorphisms on chromosome 4q25, 16q22 and 1q21 correlate with atrial fibrillation (AF). However, the distribution of these polymorphisms differs significantly among populations.<h4>Objective</h4>To test the polymorphisms on chromosome 4q25, 16q22 and 1q21 in a group of patients (pts) that underwent catheter ablation of AF.<h4>Methods</h4>Four hundred and ten patients with AF that underwent pulmonary vein isolation were included in the study. Control group (n = 550) was taken from healthy population, matched for age, sex and presence of hypertension. All participants were genotyped for the presence of the rs2200733, rs10033464, rs17570669, rs3853445, rs6838973 (4q25), rs7193343 (16q22) and rs13376333 (1q21) polymorphisms.<h4>Results</h4>All the polymorphisms tested (except rs17570669) correlated significantly with AF in univariate analysis (p values between 0.039 for rs7193343 and 2.7e-27 for rs2200733), with the odds ratio (OR) 0.572 and 0.617 for rs3853445 and rs6838973, respectively (protective role) and OR 1.268 to 3.52 for the other polymorphisms. All 4q25 SNPs tested but rs3853445 were independently linked with AF in multivariate logistic regression analysis. In haplotype analysis six out of nine 4q25 haplotypes were significantly linked with AF. The T allele of rs2200733 favoured increased number of episodes of AF per month (p = 0.045) and larger pulmonary vein diameter (recessive model, p = 0.032).<h4>Conclusions</h4>Patients qualified for catheter ablation of AF have a significantly higher frequency of 4q25, 16q22 and 1q21 variants than the control group. The T allele of rs2200733 favours larger pulmonary veins and increased number of episodes of AF.
format	article
author	Marek Kiliszek Maria Franaszczyk Edward Kozluk Piotr Lodzinski Agnieszka Piatkowska Grażyna Broda Rafal Ploski Grzegorz Opolski
author_facet	Marek Kiliszek Maria Franaszczyk Edward Kozluk Piotr Lodzinski Agnieszka Piatkowska Grażyna Broda Rafal Ploski Grzegorz Opolski
author_sort	Marek Kiliszek
title	Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.
title_short	Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.
title_full	Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.
title_fullStr	Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.
title_full_unstemmed	Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.
title_sort	association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the polish population.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e490e2cfe8bc4a078e83efe7039baf6f
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Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population.

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