Manufacturing Process of Polymeric Microneedle Sensors for Mass Production

In this work, we present a fabrication process for microneedle sensors made of polylactic acid (PLA), which can be utilized for the electrochemical detection of various biomarkers in interstitial fluid. Microneedles were fabricated by the thermal compression molding of PLA into a laser machined poly...

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Autores principales:	Jae Yun Baek, Kyung Mook Kang, Hyeong Jun Kim, Ju Hyeon Kim, Ju Hwan Lee, Gilyong Shin, Jei Gyeong Jeon, Junho Lee, Yusu Han, Byeong Jun So, Tae June Kang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microneedle laser machining polylactic acid electrochemical detection biomolecules Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/e49780ece910474785add08b94153950
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id	oai:doaj.org-article:e49780ece910474785add08b94153950
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spelling	oai:doaj.org-article:e49780ece910474785add08b941539502021-11-25T18:23:25ZManufacturing Process of Polymeric Microneedle Sensors for Mass Production10.3390/mi121113642072-666Xhttps://doaj.org/article/e49780ece910474785add08b941539502021-11-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1364https://doaj.org/toc/2072-666XIn this work, we present a fabrication process for microneedle sensors made of polylactic acid (PLA), which can be utilized for the electrochemical detection of various biomarkers in interstitial fluid. Microneedles were fabricated by the thermal compression molding of PLA into a laser machined polytetrafluoroethylene (PTFE) mold. Sensor fabrication was completed by forming working, counter, and reference electrodes on each sensor surface by Au sputtering through a stencil mask, followed by laser dicing to separate individual sensors from the substrate. The devised series of processes was designed to be suitable for mass production, where multiple microneedle sensors can be produced at once on a 4-inch wafer. The operational stability of the fabricated sensors was confirmed by linear sweep voltammetry and cyclic voltammetry at the range of working potentials of various biochemical molecules in interstitial fluid.Jae Yun BaekKyung Mook KangHyeong Jun KimJu Hyeon KimJu Hwan LeeGilyong ShinJei Gyeong JeonJunho LeeYusu HanByeong Jun SoTae June KangMDPI AGarticlemicroneedlelaser machiningpolylactic acidelectrochemical detectionbiomoleculesMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1364, p 1364 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microneedle laser machining polylactic acid electrochemical detection biomolecules Mechanical engineering and machinery TJ1-1570
spellingShingle	microneedle laser machining polylactic acid electrochemical detection biomolecules Mechanical engineering and machinery TJ1-1570 Jae Yun Baek Kyung Mook Kang Hyeong Jun Kim Ju Hyeon Kim Ju Hwan Lee Gilyong Shin Jei Gyeong Jeon Junho Lee Yusu Han Byeong Jun So Tae June Kang Manufacturing Process of Polymeric Microneedle Sensors for Mass Production
description	In this work, we present a fabrication process for microneedle sensors made of polylactic acid (PLA), which can be utilized for the electrochemical detection of various biomarkers in interstitial fluid. Microneedles were fabricated by the thermal compression molding of PLA into a laser machined polytetrafluoroethylene (PTFE) mold. Sensor fabrication was completed by forming working, counter, and reference electrodes on each sensor surface by Au sputtering through a stencil mask, followed by laser dicing to separate individual sensors from the substrate. The devised series of processes was designed to be suitable for mass production, where multiple microneedle sensors can be produced at once on a 4-inch wafer. The operational stability of the fabricated sensors was confirmed by linear sweep voltammetry and cyclic voltammetry at the range of working potentials of various biochemical molecules in interstitial fluid.
format	article
author	Jae Yun Baek Kyung Mook Kang Hyeong Jun Kim Ju Hyeon Kim Ju Hwan Lee Gilyong Shin Jei Gyeong Jeon Junho Lee Yusu Han Byeong Jun So Tae June Kang
author_facet	Jae Yun Baek Kyung Mook Kang Hyeong Jun Kim Ju Hyeon Kim Ju Hwan Lee Gilyong Shin Jei Gyeong Jeon Junho Lee Yusu Han Byeong Jun So Tae June Kang
author_sort	Jae Yun Baek
title	Manufacturing Process of Polymeric Microneedle Sensors for Mass Production
title_short	Manufacturing Process of Polymeric Microneedle Sensors for Mass Production
title_full	Manufacturing Process of Polymeric Microneedle Sensors for Mass Production
title_fullStr	Manufacturing Process of Polymeric Microneedle Sensors for Mass Production
title_full_unstemmed	Manufacturing Process of Polymeric Microneedle Sensors for Mass Production
title_sort	manufacturing process of polymeric microneedle sensors for mass production
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e49780ece910474785add08b94153950
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_version_	1718411230628020224

Manufacturing Process of Polymeric Microneedle Sensors for Mass Production

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