Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.

<h4>Objective</h4>Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a princi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	P Roberto Bakker, Egbert Bakker, Najaf Amin, Cornelia M van Duijn, Jim van Os, Peter N van Harten
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e499a3d369454b9cb1adbf041a9236ad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e499a3d369454b9cb1adbf041a9236ad
record_format	dspace
spelling	oai:doaj.org-article:e499a3d369454b9cb1adbf041a9236ad2021-11-18T07:18:45ZCandidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.1932-620310.1371/journal.pone.0036561https://doaj.org/article/e499a3d369454b9cb1adbf041a9236ad2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22615781/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, and RGS2).<h4>Methods</h4>Naturalistic study of 168 white long-stay patients with chronic mental illness requiring long-term antipsychotic treatment, examined by the same rater at least two times over a 4-year period, with a mean follow-up time of 1.1 years, with validated scales for TD, parkinsonism, akathisia, and tardive dystonia. The authors genotyped 31 SNPs, associated with movement disorders or schizophrenia in previous studies. Genotype and allele frequency comparisons were performed with multiple regression methods for continuous movement disorders.<h4>Results</h4>VARIOUS SNPS REACHED NOMINAL SIGNIFICANCE: TD and orofacial dyskinesia with rs6265 and rs988748, limb truncal dyskinesia with rs6314, rest tremor with rs6275, rigidity with rs6265 and rs4680, bradykinesia with rs4795390, akathisia with rs4680, tardive dystonia with rs1799732, rs4880 and rs1152746. After controlling for multiple testing, no significant results remained.<h4>Conclusions</h4>The findings suggest that selected SNPs are not associated with a susceptibility to movement disorders. However, as the sample size was small and previous studies show inconsistent results, definite conclusions cannot be made. Replication is needed in larger study samples, preferably in longitudinal studies which take the fluctuating course of movement disorders and gene-environment interactions into account.P Roberto BakkerEgbert BakkerNajaf AminCornelia M van DuijnJim van OsPeter N van HartenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36561 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q P Roberto Bakker Egbert Bakker Najaf Amin Cornelia M van Duijn Jim van Os Peter N van Harten Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
description	<h4>Objective</h4>Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, and RGS2).<h4>Methods</h4>Naturalistic study of 168 white long-stay patients with chronic mental illness requiring long-term antipsychotic treatment, examined by the same rater at least two times over a 4-year period, with a mean follow-up time of 1.1 years, with validated scales for TD, parkinsonism, akathisia, and tardive dystonia. The authors genotyped 31 SNPs, associated with movement disorders or schizophrenia in previous studies. Genotype and allele frequency comparisons were performed with multiple regression methods for continuous movement disorders.<h4>Results</h4>VARIOUS SNPS REACHED NOMINAL SIGNIFICANCE: TD and orofacial dyskinesia with rs6265 and rs988748, limb truncal dyskinesia with rs6314, rest tremor with rs6275, rigidity with rs6265 and rs4680, bradykinesia with rs4795390, akathisia with rs4680, tardive dystonia with rs1799732, rs4880 and rs1152746. After controlling for multiple testing, no significant results remained.<h4>Conclusions</h4>The findings suggest that selected SNPs are not associated with a susceptibility to movement disorders. However, as the sample size was small and previous studies show inconsistent results, definite conclusions cannot be made. Replication is needed in larger study samples, preferably in longitudinal studies which take the fluctuating course of movement disorders and gene-environment interactions into account.
format	article
author	P Roberto Bakker Egbert Bakker Najaf Amin Cornelia M van Duijn Jim van Os Peter N van Harten
author_facet	P Roberto Bakker Egbert Bakker Najaf Amin Cornelia M van Duijn Jim van Os Peter N van Harten
author_sort	P Roberto Bakker
title	Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
title_short	Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
title_full	Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
title_fullStr	Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
title_full_unstemmed	Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
title_sort	candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e499a3d369454b9cb1adbf041a9236ad
work_keys_str_mv	AT probertobakker candidategenebasedassociationstudyofantipsychoticinducedmovementdisordersinlongstaypsychiatricpatientsaprospectivestudy AT egbertbakker candidategenebasedassociationstudyofantipsychoticinducedmovementdisordersinlongstaypsychiatricpatientsaprospectivestudy AT najafamin candidategenebasedassociationstudyofantipsychoticinducedmovementdisordersinlongstaypsychiatricpatientsaprospectivestudy AT corneliamvanduijn candidategenebasedassociationstudyofantipsychoticinducedmovementdisordersinlongstaypsychiatricpatientsaprospectivestudy AT jimvanos candidategenebasedassociationstudyofantipsychoticinducedmovementdisordersinlongstaypsychiatricpatientsaprospectivestudy AT peternvanharten candidategenebasedassociationstudyofantipsychoticinducedmovementdisordersinlongstaypsychiatricpatientsaprospectivestudy
_version_	1718423697391353856

Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.

Ejemplares similares