Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants

The human SFTPA1 and SFTPA2 genes encode the surfactant protein A1 (SP-A1) and SP-A2, respectively, and they have been identified with significant genetic and epigenetic variability including sequence, deletion/insertions, and splice variants. The surfactant proteins, SP-A1 and SP-A2, and their corr...

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Autores principales:	Joanna Floros, Nikolaos Tsotakos
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	transcription regulation variants posttranscriptional regulation promoter surfactant protein A (SP-A) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e499d5a68cca4cb0a150658f6eafc286
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spelling	oai:doaj.org-article:e499d5a68cca4cb0a150658f6eafc2862021-12-01T18:24:46ZDifferential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants1664-322410.3389/fimmu.2021.766719https://doaj.org/article/e499d5a68cca4cb0a150658f6eafc2862021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.766719/fullhttps://doaj.org/toc/1664-3224The human SFTPA1 and SFTPA2 genes encode the surfactant protein A1 (SP-A1) and SP-A2, respectively, and they have been identified with significant genetic and epigenetic variability including sequence, deletion/insertions, and splice variants. The surfactant proteins, SP-A1 and SP-A2, and their corresponding variants play important roles in several processes of innate immunity as well in surfactant-related functions as reviewed elsewhere [1]. The levels of SP-A have been shown to differ among individuals both under baseline conditions and in response to various agents or disease states. Moreover, a number of agents have been shown to differentially regulate SFTPA1 and SFTPA2 transcripts. The focus in this review is on the differential regulation of SFTPA1 and SFTPA2 with primary focus on the role of 5′ and 3′ untranslated regions (UTRs) and flanking sequences on this differential regulation as well molecules that may mediate the differential regulation.Joanna FlorosJoanna FlorosNikolaos TsotakosFrontiers Media S.A.articletranscription regulationvariantsposttranscriptional regulationpromotersurfactant protein A (SP-A)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transcription regulation variants posttranscriptional regulation promoter surfactant protein A (SP-A) Immunologic diseases. Allergy RC581-607
spellingShingle	transcription regulation variants posttranscriptional regulation promoter surfactant protein A (SP-A) Immunologic diseases. Allergy RC581-607 Joanna Floros Joanna Floros Nikolaos Tsotakos Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants
description	The human SFTPA1 and SFTPA2 genes encode the surfactant protein A1 (SP-A1) and SP-A2, respectively, and they have been identified with significant genetic and epigenetic variability including sequence, deletion/insertions, and splice variants. The surfactant proteins, SP-A1 and SP-A2, and their corresponding variants play important roles in several processes of innate immunity as well in surfactant-related functions as reviewed elsewhere [1]. The levels of SP-A have been shown to differ among individuals both under baseline conditions and in response to various agents or disease states. Moreover, a number of agents have been shown to differentially regulate SFTPA1 and SFTPA2 transcripts. The focus in this review is on the differential regulation of SFTPA1 and SFTPA2 with primary focus on the role of 5′ and 3′ untranslated regions (UTRs) and flanking sequences on this differential regulation as well molecules that may mediate the differential regulation.
format	article
author	Joanna Floros Joanna Floros Nikolaos Tsotakos
author_facet	Joanna Floros Joanna Floros Nikolaos Tsotakos
author_sort	Joanna Floros
title	Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants
title_short	Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants
title_full	Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants
title_fullStr	Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants
title_full_unstemmed	Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants
title_sort	differential regulation of human surfactant protein a genes, sftpa1 and sftpa2, and their corresponding variants
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e499d5a68cca4cb0a150658f6eafc286
work_keys_str_mv	AT joannafloros differentialregulationofhumansurfactantproteinagenessftpa1andsftpa2andtheircorrespondingvariants AT joannafloros differentialregulationofhumansurfactantproteinagenessftpa1andsftpa2andtheircorrespondingvariants AT nikolaostsotakos differentialregulationofhumansurfactantproteinagenessftpa1andsftpa2andtheircorrespondingvariants
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Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants

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