Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.

<h4>Context</h4>Nonfasting (postprandial) triglyceride concentrations have emerged as a clinically significant cardiovascular disease risk factor that results from accumulation of remnant triglyceride-rich lipoproteins (TRLs) in the circulation. The remnant TRLs are cleared from the circ...

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Autores principales:	Niina Matikainen, Maria Antonella Burza, Stefano Romeo, Antti Hakkarainen, Martin Adiels, Lasse Folkersen, Per Eriksson, Nina Lundbom, Ewa Ehrenborg, Marju Orho-Melander, Marja-Riitta Taskinen, Jan Borén
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e49be2d8d6e1427aab8705ca4e8542e7
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spelling	oai:doaj.org-article:e49be2d8d6e1427aab8705ca4e8542e72021-11-18T08:45:34ZGenetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.1932-620310.1371/journal.pone.0079473https://doaj.org/article/e49be2d8d6e1427aab8705ca4e8542e72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278138/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Context</h4>Nonfasting (postprandial) triglyceride concentrations have emerged as a clinically significant cardiovascular disease risk factor that results from accumulation of remnant triglyceride-rich lipoproteins (TRLs) in the circulation. The remnant TRLs are cleared from the circulation by hepatic uptake, but the specific mechanisms involved are unclear. The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway is important for the hepatic clearance of remnant TRLs in mice, but its relevance in humans is unclear.<h4>Objective</h4>We sought to determine whether polymorphisms of the genes responsible for HSPG assembly and disassembly contribute to atherogenic dyslipoproteinemias in humans.<h4>Patients and design</h4>We performed an oral fat load in 68 healthy subjects. Lipoproteins (chylomicrons and very low density lipoproteins 1 and 2) were isolated from blood, and the area under curve and incremental area under curve for postprandial variables were calculated. Single nucleotide polymorphisms in genes encoding syndecan-1 and enzymes involved in the synthesis or degradation of HSPG were genotyped in the study subjects.<h4>Results</h4>Our results indicate that the genetic variation rs2281279 in SULF2 associates with postprandial clearance of remnant TRLs and triglyceride levels in healthy subjects. Furthermore, the SNP rs2281279 in SULF2 associates with hepatic SULF2 mRNA levels.<h4>Conclusions</h4>In humans, mild but clinically relevant postprandial hyperlipidemia due to reduced hepatic clearance of remnant TRLs may result from genetic polymorphisms that affect hepatic HSPG.Niina MatikainenMaria Antonella BurzaStefano RomeoAntti HakkarainenMartin AdielsLasse FolkersenPer ErikssonNina LundbomEwa EhrenborgMarju Orho-MelanderMarja-Riitta TaskinenJan BorénPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79473 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Niina Matikainen Maria Antonella Burza Stefano Romeo Antti Hakkarainen Martin Adiels Lasse Folkersen Per Eriksson Nina Lundbom Ewa Ehrenborg Marju Orho-Melander Marja-Riitta Taskinen Jan Borén Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
description	<h4>Context</h4>Nonfasting (postprandial) triglyceride concentrations have emerged as a clinically significant cardiovascular disease risk factor that results from accumulation of remnant triglyceride-rich lipoproteins (TRLs) in the circulation. The remnant TRLs are cleared from the circulation by hepatic uptake, but the specific mechanisms involved are unclear. The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway is important for the hepatic clearance of remnant TRLs in mice, but its relevance in humans is unclear.<h4>Objective</h4>We sought to determine whether polymorphisms of the genes responsible for HSPG assembly and disassembly contribute to atherogenic dyslipoproteinemias in humans.<h4>Patients and design</h4>We performed an oral fat load in 68 healthy subjects. Lipoproteins (chylomicrons and very low density lipoproteins 1 and 2) were isolated from blood, and the area under curve and incremental area under curve for postprandial variables were calculated. Single nucleotide polymorphisms in genes encoding syndecan-1 and enzymes involved in the synthesis or degradation of HSPG were genotyped in the study subjects.<h4>Results</h4>Our results indicate that the genetic variation rs2281279 in SULF2 associates with postprandial clearance of remnant TRLs and triglyceride levels in healthy subjects. Furthermore, the SNP rs2281279 in SULF2 associates with hepatic SULF2 mRNA levels.<h4>Conclusions</h4>In humans, mild but clinically relevant postprandial hyperlipidemia due to reduced hepatic clearance of remnant TRLs may result from genetic polymorphisms that affect hepatic HSPG.
format	article
author	Niina Matikainen Maria Antonella Burza Stefano Romeo Antti Hakkarainen Martin Adiels Lasse Folkersen Per Eriksson Nina Lundbom Ewa Ehrenborg Marju Orho-Melander Marja-Riitta Taskinen Jan Borén
author_facet	Niina Matikainen Maria Antonella Burza Stefano Romeo Antti Hakkarainen Martin Adiels Lasse Folkersen Per Eriksson Nina Lundbom Ewa Ehrenborg Marju Orho-Melander Marja-Riitta Taskinen Jan Borén
author_sort	Niina Matikainen
title	Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
title_short	Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
title_full	Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
title_fullStr	Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
title_full_unstemmed	Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
title_sort	genetic variation in sulf2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e49be2d8d6e1427aab8705ca4e8542e7
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Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.

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