Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering

Abalone shells, which contain both organic and inorganic matter, can facilitate bone remodeling and have been used to fabricate three-dimensional (3D)-printed scaffolds for bone regeneration. Herein, polycaprolactone (PCL) scaffolds were fabricated using 3D printing with abalone shell particles (ASP...

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Autores principales:	Dahong Kim, Jihye Lee, Ji Min Seok, Joo-Yun Jung, Jun Hee Lee, Jun Sik Lee, Kangwon Lee, Su A Park
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Three-dimensional printing Abalone shell Bone tissue engineering Bone scaffold Bioactive scaffold Marine organism Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/e49c32750a1e4e31bd819a5f265a955b
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id	oai:doaj.org-article:e49c32750a1e4e31bd819a5f265a955b
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spelling	oai:doaj.org-article:e49c32750a1e4e31bd819a5f265a955b2021-11-18T04:43:27ZThree-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering0264-127510.1016/j.matdes.2021.110228https://doaj.org/article/e49c32750a1e4e31bd819a5f265a955b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0264127521007838https://doaj.org/toc/0264-1275Abalone shells, which contain both organic and inorganic matter, can facilitate bone remodeling and have been used to fabricate three-dimensional (3D)-printed scaffolds for bone regeneration. Herein, polycaprolactone (PCL) scaffolds were fabricated using 3D printing with abalone shell particles (ASPs) used in high-temperature processing. ASPs were heated to approximately the melting point of PCL and thermally embedded in 3D-printed PCL using a relatively simple process. The morphology and roughness of the composite scaffold changed according to the weight of ASPs used. The scaffolds were grouped as follows: ASP25 (25 mg), ASP50 (50 mg), and ASP100 (100 mg). The ASP25 group exhibited optimum cell viability and proliferation because of the direct influence of roughness and rapid pH changes. The ASP25 and ASP100 groups showed the highest alkaline phosphatase activity. This could be attributed to the effect of the alkaline environment, dissolution of calcium ions, and presence of bioactive molecules in the ASPs that could support bone regeneration. Therefore, the ASP25 group was the most suitable for fabricating bone scaffolds. This study revealed the potential applicability of ASP-embedded scaffolds in bone tissue engineering involving natural bio-organisms that self-mineralize in a process similar to human bone formation.Dahong KimJihye LeeJi Min SeokJoo-Yun JungJun Hee LeeJun Sik LeeKangwon LeeSu A ParkElsevierarticleThree-dimensional printingAbalone shellBone tissue engineeringBone scaffoldBioactive scaffoldMarine organismMaterials of engineering and construction. Mechanics of materialsTA401-492ENMaterials & Design, Vol 212, Iss , Pp 110228- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Three-dimensional printing Abalone shell Bone tissue engineering Bone scaffold Bioactive scaffold Marine organism Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Three-dimensional printing Abalone shell Bone tissue engineering Bone scaffold Bioactive scaffold Marine organism Materials of engineering and construction. Mechanics of materials TA401-492 Dahong Kim Jihye Lee Ji Min Seok Joo-Yun Jung Jun Hee Lee Jun Sik Lee Kangwon Lee Su A Park Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering
description	Abalone shells, which contain both organic and inorganic matter, can facilitate bone remodeling and have been used to fabricate three-dimensional (3D)-printed scaffolds for bone regeneration. Herein, polycaprolactone (PCL) scaffolds were fabricated using 3D printing with abalone shell particles (ASPs) used in high-temperature processing. ASPs were heated to approximately the melting point of PCL and thermally embedded in 3D-printed PCL using a relatively simple process. The morphology and roughness of the composite scaffold changed according to the weight of ASPs used. The scaffolds were grouped as follows: ASP25 (25 mg), ASP50 (50 mg), and ASP100 (100 mg). The ASP25 group exhibited optimum cell viability and proliferation because of the direct influence of roughness and rapid pH changes. The ASP25 and ASP100 groups showed the highest alkaline phosphatase activity. This could be attributed to the effect of the alkaline environment, dissolution of calcium ions, and presence of bioactive molecules in the ASPs that could support bone regeneration. Therefore, the ASP25 group was the most suitable for fabricating bone scaffolds. This study revealed the potential applicability of ASP-embedded scaffolds in bone tissue engineering involving natural bio-organisms that self-mineralize in a process similar to human bone formation.
format	article
author	Dahong Kim Jihye Lee Ji Min Seok Joo-Yun Jung Jun Hee Lee Jun Sik Lee Kangwon Lee Su A Park
author_facet	Dahong Kim Jihye Lee Ji Min Seok Joo-Yun Jung Jun Hee Lee Jun Sik Lee Kangwon Lee Su A Park
author_sort	Dahong Kim
title	Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering
title_short	Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering
title_full	Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering
title_fullStr	Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering
title_full_unstemmed	Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering
title_sort	three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e49c32750a1e4e31bd819a5f265a955b
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Three-dimensional bioprinting of bioactive scaffolds with thermally embedded abalone shell particles for bone tissue engineering

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