Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy

Abstract We evaluated the cardioprotective effect of Amalaki Rasayana (AR), a rejuvenating Ayurvedic drug prepared from Phyllanthus emblica fruits in the reversal of remodeling changes in pressure overload left ventricular cardiac hypertrophy (LVH) and age-associated cardiac dysfunction in male Wist...

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Autores principales:	Vikas Kumar, kumar A. Aneesh, K. Kshemada, Kumar G. S. Ajith, Raj S. S. Binil, Neha Deora, G. Sanjay, A. Jaleel, T. S. Muraleedharan, E. M. Anandan, R. S Mony, M. S. Valiathan, Kumar T. R. Santhosh, C. C Kartha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e49ec0f70a3b4656b6b136988fafeb1e
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spelling	oai:doaj.org-article:e49ec0f70a3b4656b6b136988fafeb1e2021-12-02T11:51:11ZAmalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy10.1038/s41598-017-09225-x2045-2322https://doaj.org/article/e49ec0f70a3b4656b6b136988fafeb1e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09225-xhttps://doaj.org/toc/2045-2322Abstract We evaluated the cardioprotective effect of Amalaki Rasayana (AR), a rejuvenating Ayurvedic drug prepared from Phyllanthus emblica fruits in the reversal of remodeling changes in pressure overload left ventricular cardiac hypertrophy (LVH) and age-associated cardiac dysfunction in male Wistar rats. Six groups (aging groups) of 3 months old animals were given either AR or ghee and honey (GH) orally; seventh group was untreated. Ascending aorta was constricted using titanium clips in 3 months old rats (N = 24; AC groups) and after 6 months, AR or GH was given for further 12 months to two groups; one group was untreated. Histology, gene and protein expression analysis were done in heart tissues. Chemical composition of AR was analyzed by HPLC, HPTLC and LC-MS. AR intake improved (P < 0.05) cardiac function in aging rats and decreased LVH (P < 0.05) in AC rats as well as increased (P < 0.05) fatigue time in treadmill exercise in both groups. In heart tissues of AR administered rats of both the groups, SERCA2, CaM, Myh11, antioxidant, autophagy, oxidative phosphorylation and TCA cycle proteins were up regulated. ADRB1/2 and pCREB expression were increased; pAMPK, NF-kB were decreased. AR has thus a beneficial effect on myocardial energetics, muscle contractile function and exercise tolerance capacity.Vikas Kumarkumar A. AneeshK. KshemadaKumar G. S. AjithRaj S. S. BinilNeha DeoraG. SanjayA. JaleelT. S. MuraleedharanE. M. AnandanR. S MonyM. S. ValiathanKumar T. R. SanthoshC. C KarthaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vikas Kumar kumar A. Aneesh K. Kshemada Kumar G. S. Ajith Raj S. S. Binil Neha Deora G. Sanjay A. Jaleel T. S. Muraleedharan E. M. Anandan R. S Mony M. S. Valiathan Kumar T. R. Santhosh C. C Kartha Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
description	Abstract We evaluated the cardioprotective effect of Amalaki Rasayana (AR), a rejuvenating Ayurvedic drug prepared from Phyllanthus emblica fruits in the reversal of remodeling changes in pressure overload left ventricular cardiac hypertrophy (LVH) and age-associated cardiac dysfunction in male Wistar rats. Six groups (aging groups) of 3 months old animals were given either AR or ghee and honey (GH) orally; seventh group was untreated. Ascending aorta was constricted using titanium clips in 3 months old rats (N = 24; AC groups) and after 6 months, AR or GH was given for further 12 months to two groups; one group was untreated. Histology, gene and protein expression analysis were done in heart tissues. Chemical composition of AR was analyzed by HPLC, HPTLC and LC-MS. AR intake improved (P < 0.05) cardiac function in aging rats and decreased LVH (P < 0.05) in AC rats as well as increased (P < 0.05) fatigue time in treadmill exercise in both groups. In heart tissues of AR administered rats of both the groups, SERCA2, CaM, Myh11, antioxidant, autophagy, oxidative phosphorylation and TCA cycle proteins were up regulated. ADRB1/2 and pCREB expression were increased; pAMPK, NF-kB were decreased. AR has thus a beneficial effect on myocardial energetics, muscle contractile function and exercise tolerance capacity.
format	article
author	Vikas Kumar kumar A. Aneesh K. Kshemada Kumar G. S. Ajith Raj S. S. Binil Neha Deora G. Sanjay A. Jaleel T. S. Muraleedharan E. M. Anandan R. S Mony M. S. Valiathan Kumar T. R. Santhosh C. C Kartha
author_facet	Vikas Kumar kumar A. Aneesh K. Kshemada Kumar G. S. Ajith Raj S. S. Binil Neha Deora G. Sanjay A. Jaleel T. S. Muraleedharan E. M. Anandan R. S Mony M. S. Valiathan Kumar T. R. Santhosh C. C Kartha
author_sort	Vikas Kumar
title	Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
title_short	Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
title_full	Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
title_fullStr	Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
title_full_unstemmed	Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
title_sort	amalaki rasayana, a traditional indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e49ec0f70a3b4656b6b136988fafeb1e
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Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy

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