4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement

Abstract The objectives of this study were to determine whether 4 days of dry immersion (DI) induced similar arterial aging as spaceflight and to test the impact of thigh cuffs. Eighteen subjects underwent DI; nine wore thigh cuffs. Cardiac and arterial targets were assessed by ultrasound. No signif...

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Autores principales:	Danielle Greaves, Laurent Guillon, Stephane Besnard, Nastassia Navasiolava, Philippe Arbeille
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/e4a2032f319f4b9b9f1d37581b3789a8
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spelling	oai:doaj.org-article:e4a2032f319f4b9b9f1d37581b3789a82021-11-08T11:01:38Z4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement10.1038/s41526-021-00172-62373-8065https://doaj.org/article/e4a2032f319f4b9b9f1d37581b3789a82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00172-6https://doaj.org/toc/2373-8065Abstract The objectives of this study were to determine whether 4 days of dry immersion (DI) induced similar arterial aging as spaceflight and to test the impact of thigh cuffs. Eighteen subjects underwent DI; nine wore thigh cuffs. Cardiac and arterial targets were assessed by ultrasound. No significant differences were found between the groups. The left ventricle volume, stroke volume (SV), and ejection fraction decreased with DI (p < 0.001). Carotid distensibility reduced (p < 0.05), carotid to femoral arterial tree became stiffer in 33% of the subjects, and femoral artery intima media thickness increased (p < 0.05). A reduction in plasma volume is likely to have caused the observed cardiac changes, whereas the arterial wall changes are probably best explained by hypokinesia and/or environmental stress. These changes are similar but lower in amplitude than those observed in spaceflight and mimic the natural aging effect on earth. The daytime-worn thigh cuffs had no acute or chronic impact on these arterial-focused measurements.Danielle GreavesLaurent GuillonStephane BesnardNastassia NavasiolavaPhilippe ArbeilleNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Danielle Greaves Laurent Guillon Stephane Besnard Nastassia Navasiolava Philippe Arbeille 4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement
description	Abstract The objectives of this study were to determine whether 4 days of dry immersion (DI) induced similar arterial aging as spaceflight and to test the impact of thigh cuffs. Eighteen subjects underwent DI; nine wore thigh cuffs. Cardiac and arterial targets were assessed by ultrasound. No significant differences were found between the groups. The left ventricle volume, stroke volume (SV), and ejection fraction decreased with DI (p < 0.001). Carotid distensibility reduced (p < 0.05), carotid to femoral arterial tree became stiffer in 33% of the subjects, and femoral artery intima media thickness increased (p < 0.05). A reduction in plasma volume is likely to have caused the observed cardiac changes, whereas the arterial wall changes are probably best explained by hypokinesia and/or environmental stress. These changes are similar but lower in amplitude than those observed in spaceflight and mimic the natural aging effect on earth. The daytime-worn thigh cuffs had no acute or chronic impact on these arterial-focused measurements.
format	article
author	Danielle Greaves Laurent Guillon Stephane Besnard Nastassia Navasiolava Philippe Arbeille
author_facet	Danielle Greaves Laurent Guillon Stephane Besnard Nastassia Navasiolava Philippe Arbeille
author_sort	Danielle Greaves
title	4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement
title_short	4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement
title_full	4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement
title_fullStr	4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement
title_full_unstemmed	4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement
title_sort	4 day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e4a2032f319f4b9b9f1d37581b3789a8
work_keys_str_mv	AT daniellegreaves 4dayindryimmersionreproducespartiallytheagingeffectonthearteriesasobservedduring6monthspaceflightorconfinement AT laurentguillon 4dayindryimmersionreproducespartiallytheagingeffectonthearteriesasobservedduring6monthspaceflightorconfinement AT stephanebesnard 4dayindryimmersionreproducespartiallytheagingeffectonthearteriesasobservedduring6monthspaceflightorconfinement AT nastassianavasiolava 4dayindryimmersionreproducespartiallytheagingeffectonthearteriesasobservedduring6monthspaceflightorconfinement AT philippearbeille 4dayindryimmersionreproducespartiallytheagingeffectonthearteriesasobservedduring6monthspaceflightorconfinement
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4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement

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