Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity

Decoy binding sites are natural regulators of gene expression. Here the authors design synthetic DNA sponges that fine tune the performance of synthetic gene circuits in a simple yet systematic manner, expanding the synthetic biology toolkit for gene regulation.

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Autores principales:	Xinyi Wan, Filipe Pinto, Luyang Yu, Baojun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4a57ff200554f71a938d172cff1cbd6
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spelling	oai:doaj.org-article:e4a57ff200554f71a938d172cff1cbd62021-12-02T13:57:34ZSynthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity10.1038/s41467-020-19552-92041-1723https://doaj.org/article/e4a57ff200554f71a938d172cff1cbd62020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19552-9https://doaj.org/toc/2041-1723Decoy binding sites are natural regulators of gene expression. Here the authors design synthetic DNA sponges that fine tune the performance of synthetic gene circuits in a simple yet systematic manner, expanding the synthetic biology toolkit for gene regulation.Xinyi WanFilipe PintoLuyang YuBaojun WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinyi Wan Filipe Pinto Luyang Yu Baojun Wang Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
description	Decoy binding sites are natural regulators of gene expression. Here the authors design synthetic DNA sponges that fine tune the performance of synthetic gene circuits in a simple yet systematic manner, expanding the synthetic biology toolkit for gene regulation.
format	article
author	Xinyi Wan Filipe Pinto Luyang Yu Baojun Wang
author_facet	Xinyi Wan Filipe Pinto Luyang Yu Baojun Wang
author_sort	Xinyi Wan
title	Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
title_short	Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
title_full	Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
title_fullStr	Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
title_full_unstemmed	Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
title_sort	synthetic protein-binding dna sponge as a tool to tune gene expression and mitigate protein toxicity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e4a57ff200554f71a938d172cff1cbd6
work_keys_str_mv	AT xinyiwan syntheticproteinbindingdnaspongeasatooltotunegeneexpressionandmitigateproteintoxicity AT filipepinto syntheticproteinbindingdnaspongeasatooltotunegeneexpressionandmitigateproteintoxicity AT luyangyu syntheticproteinbindingdnaspongeasatooltotunegeneexpressionandmitigateproteintoxicity AT baojunwang syntheticproteinbindingdnaspongeasatooltotunegeneexpressionandmitigateproteintoxicity
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Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity

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