A computational study of branch-wise curvature in idealized coronary artery bifurcations

The curvature of coronary arteries can significantly influence their hemodynamics, particularly at coronary bifurcations. The present work aims to investigate the effect of individual branch curvatures on atherosclerotic susceptibility using idealized left coronary bifurcations with dimensions from...

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Autores principales:	Vishesh Kashyap, B.B. Arora, Sourajit Bhattacharjee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2020
Materias:	Hemodynamics Coronary artery bifurcation Artery curvature CFD Wall shear stress Idealized model Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/e4a7aaba0f544d9da3a4243a1de5654c
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id	oai:doaj.org-article:e4a7aaba0f544d9da3a4243a1de5654c
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spelling	oai:doaj.org-article:e4a7aaba0f544d9da3a4243a1de5654c2021-12-01T05:05:47ZA computational study of branch-wise curvature in idealized coronary artery bifurcations2666-496810.1016/j.apples.2020.100027https://doaj.org/article/e4a7aaba0f544d9da3a4243a1de5654c2020-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666496820300273https://doaj.org/toc/2666-4968The curvature of coronary arteries can significantly influence their hemodynamics, particularly at coronary bifurcations. The present work aims to investigate the effect of individual branch curvatures on atherosclerotic susceptibility using idealized left coronary bifurcations with dimensions from literature, through computational fluid dynamics (CFD). The bend angle has been used as the metric for curvature, being varied from 0° to 60° for each branch to cover a majority of the population, while keeping the other two branches at 0°. Hemodynamic indicators time-averaged wall shear stress (TAWSS), oscillating shear index (OSI) and relative residence time (RRT) have been studied in the analysis. The results indicate that the individual curvature of each branch of the coronary bifurcation has an impact on the hemodynamics of all three branches. The curvature of either of the branches most significantly impacts the LAD branch, with an increase in the low TAWSS (12% for LM and 20% for LAD branch curvature) and high RRT areas (13% for LAD and 15% for LCx branch curvature) being observed. It may hence be said to be most susceptible to the formation of atherosclerotic lesions. The OSI is observed to be impacted only in the curved branch. In general, an increase in curvature is associated with an increase in the TAWSS. The high RRT area decreases (12%) with LM branch curvature, is negligibly variant for LAD branch curvature and increases (9%) with LCx branch curvature.Vishesh KashyapB.B. AroraSourajit BhattacharjeeElsevierarticleHemodynamicsCoronary artery bifurcationArtery curvatureCFDWall shear stressIdealized modelEngineering (General). Civil engineering (General)TA1-2040ENApplications in Engineering Science, Vol 4, Iss , Pp 100027- (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hemodynamics Coronary artery bifurcation Artery curvature CFD Wall shear stress Idealized model Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	Hemodynamics Coronary artery bifurcation Artery curvature CFD Wall shear stress Idealized model Engineering (General). Civil engineering (General) TA1-2040 Vishesh Kashyap B.B. Arora Sourajit Bhattacharjee A computational study of branch-wise curvature in idealized coronary artery bifurcations
description	The curvature of coronary arteries can significantly influence their hemodynamics, particularly at coronary bifurcations. The present work aims to investigate the effect of individual branch curvatures on atherosclerotic susceptibility using idealized left coronary bifurcations with dimensions from literature, through computational fluid dynamics (CFD). The bend angle has been used as the metric for curvature, being varied from 0° to 60° for each branch to cover a majority of the population, while keeping the other two branches at 0°. Hemodynamic indicators time-averaged wall shear stress (TAWSS), oscillating shear index (OSI) and relative residence time (RRT) have been studied in the analysis. The results indicate that the individual curvature of each branch of the coronary bifurcation has an impact on the hemodynamics of all three branches. The curvature of either of the branches most significantly impacts the LAD branch, with an increase in the low TAWSS (12% for LM and 20% for LAD branch curvature) and high RRT areas (13% for LAD and 15% for LCx branch curvature) being observed. It may hence be said to be most susceptible to the formation of atherosclerotic lesions. The OSI is observed to be impacted only in the curved branch. In general, an increase in curvature is associated with an increase in the TAWSS. The high RRT area decreases (12%) with LM branch curvature, is negligibly variant for LAD branch curvature and increases (9%) with LCx branch curvature.
format	article
author	Vishesh Kashyap B.B. Arora Sourajit Bhattacharjee
author_facet	Vishesh Kashyap B.B. Arora Sourajit Bhattacharjee
author_sort	Vishesh Kashyap
title	A computational study of branch-wise curvature in idealized coronary artery bifurcations
title_short	A computational study of branch-wise curvature in idealized coronary artery bifurcations
title_full	A computational study of branch-wise curvature in idealized coronary artery bifurcations
title_fullStr	A computational study of branch-wise curvature in idealized coronary artery bifurcations
title_full_unstemmed	A computational study of branch-wise curvature in idealized coronary artery bifurcations
title_sort	computational study of branch-wise curvature in idealized coronary artery bifurcations
publisher	Elsevier
publishDate	2020
url	https://doaj.org/article/e4a7aaba0f544d9da3a4243a1de5654c
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A computational study of branch-wise curvature in idealized coronary artery bifurcations

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