Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer

Abstract Epithelial–mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a comp...

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Autores principales:	Satoshi Ishikawa, Naohiro Nishida, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Taroh Satoh, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4a82c787c9241a1b223ba2c11055c7f
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spelling	oai:doaj.org-article:e4a82c787c9241a1b223ba2c11055c7f2021-12-02T15:03:05ZComprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer10.1038/s41598-021-91102-92045-2322https://doaj.org/article/e4a82c787c9241a1b223ba2c11055c7f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91102-9https://doaj.org/toc/2045-2322Abstract Epithelial–mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete picture of this biological process is yet to be elucidated. To comprehensively profile EMT-related genes in colorectal cancer, we quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it “mesenchymal score.” This bioinformatic approach successfully identified 90 candidate EMT mediators, which are strongly predictive of survival in clinical samples. Among these candidates, we discovered that the neuronal gene ARC, possibly originating from the retrotransposon, unexpectedly plays a crucial role in EMT induction. Profiling of novel EMT mediators we demonstrated here may help understand the complexity of the EMT program and open up new avenues for therapeutic intervention in colorectal cancer.Satoshi IshikawaNaohiro NishidaShiki FujinoTakayuki OginoHidekazu TakahashiNorikatsu MiyoshiMamoru UemuraTaroh SatohHirofumi YamamotoTsunekazu MizushimaYuichiro DokiHidetoshi EguchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Satoshi Ishikawa Naohiro Nishida Shiki Fujino Takayuki Ogino Hidekazu Takahashi Norikatsu Miyoshi Mamoru Uemura Taroh Satoh Hirofumi Yamamoto Tsunekazu Mizushima Yuichiro Doki Hidetoshi Eguchi Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
description	Abstract Epithelial–mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete picture of this biological process is yet to be elucidated. To comprehensively profile EMT-related genes in colorectal cancer, we quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it “mesenchymal score.” This bioinformatic approach successfully identified 90 candidate EMT mediators, which are strongly predictive of survival in clinical samples. Among these candidates, we discovered that the neuronal gene ARC, possibly originating from the retrotransposon, unexpectedly plays a crucial role in EMT induction. Profiling of novel EMT mediators we demonstrated here may help understand the complexity of the EMT program and open up new avenues for therapeutic intervention in colorectal cancer.
format	article
author	Satoshi Ishikawa Naohiro Nishida Shiki Fujino Takayuki Ogino Hidekazu Takahashi Norikatsu Miyoshi Mamoru Uemura Taroh Satoh Hirofumi Yamamoto Tsunekazu Mizushima Yuichiro Doki Hidetoshi Eguchi
author_facet	Satoshi Ishikawa Naohiro Nishida Shiki Fujino Takayuki Ogino Hidekazu Takahashi Norikatsu Miyoshi Mamoru Uemura Taroh Satoh Hirofumi Yamamoto Tsunekazu Mizushima Yuichiro Doki Hidetoshi Eguchi
author_sort	Satoshi Ishikawa
title	Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_short	Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_full	Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_fullStr	Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_full_unstemmed	Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_sort	comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e4a82c787c9241a1b223ba2c11055c7f
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Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer

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