Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes cause...

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Autores principales: Margaret C. Costanzo, Dohoon Kim, Matthew Creegan, Kerri G. Lal, Julie A. Ake, Jeffrey R. Currier, Hendrik Streeck, Merlin L. Robb, Nelson L. Michael, Diane L. Bolton, Nicholas J. Steers, Michael A. Eller
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/e4a9908351094565842dd84f98c3598c
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Sumario:Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes caused by HIV vaccination or chronic infection.

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