Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes cause...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Margaret C. Costanzo, Dohoon Kim, Matthew Creegan, Kerri G. Lal, Julie A. Ake, Jeffrey R. Currier, Hendrik Streeck, Merlin L. Robb, Nelson L. Michael, Diane L. Bolton, Nicholas J. Steers, Michael A. Eller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4a9908351094565842dd84f98c3598c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e4a9908351094565842dd84f98c3598c
record_format	dspace
spelling	oai:doaj.org-article:e4a9908351094565842dd84f98c3598c2021-12-02T17:31:12ZTranscriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination10.1038/s41467-018-03618-w2041-1723https://doaj.org/article/e4a9908351094565842dd84f98c3598c2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03618-whttps://doaj.org/toc/2041-1723Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes caused by HIV vaccination or chronic infection.Margaret C. CostanzoDohoon KimMatthew CreeganKerri G. LalJulie A. AkeJeffrey R. CurrierHendrik StreeckMerlin L. RobbNelson L. MichaelDiane L. BoltonNicholas J. SteersMichael A. EllerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Margaret C. Costanzo Dohoon Kim Matthew Creegan Kerri G. Lal Julie A. Ake Jeffrey R. Currier Hendrik Streeck Merlin L. Robb Nelson L. Michael Diane L. Bolton Nicholas J. Steers Michael A. Eller Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
description	Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes caused by HIV vaccination or chronic infection.
format	article
author	Margaret C. Costanzo Dohoon Kim Matthew Creegan Kerri G. Lal Julie A. Ake Jeffrey R. Currier Hendrik Streeck Merlin L. Robb Nelson L. Michael Diane L. Bolton Nicholas J. Steers Michael A. Eller
author_facet	Margaret C. Costanzo Dohoon Kim Matthew Creegan Kerri G. Lal Julie A. Ake Jeffrey R. Currier Hendrik Streeck Merlin L. Robb Nelson L. Michael Diane L. Bolton Nicholas J. Steers Michael A. Eller
author_sort	Margaret C. Costanzo
title	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_short	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_full	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_fullStr	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_full_unstemmed	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_sort	transcriptomic signatures of nk cells suggest impaired responsiveness in hiv-1 infection and increased activity post-vaccination
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e4a9908351094565842dd84f98c3598c
work_keys_str_mv	AT margaretccostanzo transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT dohoonkim transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT matthewcreegan transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT kerriglal transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT julieaake transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT jeffreyrcurrier transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT hendrikstreeck transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT merlinlrobb transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT nelsonlmichael transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT dianelbolton transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT nicholasjsteers transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination AT michaelaeller transcriptomicsignaturesofnkcellssuggestimpairedresponsivenessinhiv1infectionandincreasedactivitypostvaccination
_version_	1718380706097266688

Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Ejemplares similares