Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region

Abstract More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern E...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gyula Balka, Katarzyna Podgórska, Manreetpal Singh Brar, Ádám Bálint, Daniel Cadar, Vladimir Celer, Lilla Dénes, Zuzana Dirbakova, Anna Jedryczko, Lázár Márton, Dinko Novosel, Tamaš Petrović, Ivo Sirakov, Dóra Szalay, Ivan Toplak, Frederick Chi-Ching Leung, Tomasz Stadejek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4a99aad8d4c4bef8c0c91b23edf55e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e4a99aad8d4c4bef8c0c91b23edf55e8
record_format	dspace
spelling	oai:doaj.org-article:e4a99aad8d4c4bef8c0c91b23edf55e82021-12-02T15:08:17ZGenetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region10.1038/s41598-018-26036-w2045-2322https://doaj.org/article/e4a99aad8d4c4bef8c0c91b23edf55e82018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26036-whttps://doaj.org/toc/2045-2322Abstract More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the authors collected and analyzed both recent as well as already submitted sequences comparing them to a large backbone set of available ORF5 sequences representing the full spectrum of PRRSV 1 Subtype 1 diversity to conduct a systematic phylogenetic analysis and reclassification elucidating the diversity of the virus in these countries. Moreover, further analyses of the EUROSTAT data regarding the live pig movement trends revealed their influence of virus diversity and evolution. The results indicate that besides the effect of local, isolated divergent evolution and the use of modified live vaccines, the most important factor influencing a given country’s virus diversity is the transboundary movement of live, infected animals.Gyula BalkaKatarzyna PodgórskaManreetpal Singh BrarÁdám BálintDaniel CadarVladimir CelerLilla DénesZuzana DirbakovaAnna JedryczkoLázár MártonDinko NovoselTamaš PetrovićIvo SirakovDóra SzalayIvan ToplakFrederick Chi-Ching LeungTomasz StadejekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gyula Balka Katarzyna Podgórska Manreetpal Singh Brar Ádám Bálint Daniel Cadar Vladimir Celer Lilla Dénes Zuzana Dirbakova Anna Jedryczko Lázár Márton Dinko Novosel Tamaš Petrović Ivo Sirakov Dóra Szalay Ivan Toplak Frederick Chi-Ching Leung Tomasz Stadejek Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region
description	Abstract More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the authors collected and analyzed both recent as well as already submitted sequences comparing them to a large backbone set of available ORF5 sequences representing the full spectrum of PRRSV 1 Subtype 1 diversity to conduct a systematic phylogenetic analysis and reclassification elucidating the diversity of the virus in these countries. Moreover, further analyses of the EUROSTAT data regarding the live pig movement trends revealed their influence of virus diversity and evolution. The results indicate that besides the effect of local, isolated divergent evolution and the use of modified live vaccines, the most important factor influencing a given country’s virus diversity is the transboundary movement of live, infected animals.
format	article
author	Gyula Balka Katarzyna Podgórska Manreetpal Singh Brar Ádám Bálint Daniel Cadar Vladimir Celer Lilla Dénes Zuzana Dirbakova Anna Jedryczko Lázár Márton Dinko Novosel Tamaš Petrović Ivo Sirakov Dóra Szalay Ivan Toplak Frederick Chi-Ching Leung Tomasz Stadejek
author_facet	Gyula Balka Katarzyna Podgórska Manreetpal Singh Brar Ádám Bálint Daniel Cadar Vladimir Celer Lilla Dénes Zuzana Dirbakova Anna Jedryczko Lázár Márton Dinko Novosel Tamaš Petrović Ivo Sirakov Dóra Szalay Ivan Toplak Frederick Chi-Ching Leung Tomasz Stadejek
author_sort	Gyula Balka
title	Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region
title_short	Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region
title_full	Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region
title_fullStr	Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region
title_full_unstemmed	Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region
title_sort	genetic diversity of prrsv 1 in central eastern europe in 1994–2014: origin and evolution of the virus in the region
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e4a99aad8d4c4bef8c0c91b23edf55e8
work_keys_str_mv	AT gyulabalka geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT katarzynapodgorska geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT manreetpalsinghbrar geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT adambalint geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT danielcadar geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT vladimirceler geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT lilladenes geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT zuzanadirbakova geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT annajedryczko geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT lazarmarton geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT dinkonovosel geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT tamaspetrovic geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT ivosirakov geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT doraszalay geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT ivantoplak geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT frederickchichingleung geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion AT tomaszstadejek geneticdiversityofprrsv1incentraleasterneuropein19942014originandevolutionofthevirusintheregion
_version_	1718388222337220608

Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region

Ejemplares similares