DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in MLL-AF4 leukemia cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4a9cce559524c16a138443251705752
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e4a9cce559524c16a138443251705752
record_format	dspace
spelling	oai:doaj.org-article:e4a9cce559524c16a1384432517057522021-12-02T17:31:38ZDOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation10.1038/s41467-019-10844-32041-1723https://doaj.org/article/e4a9cce559524c16a1384432517057522019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10844-3https://doaj.org/toc/2041-1723Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in MLL-AF4 leukemia cells.Laura GodfreyNicholas T. CrumpRoss ThorneI-Jun LauEmmanouela RepapiDimitra DimouAlastair L. SmithJoe R. HarmanJelena M. TeleniusA. Marieke OudelaarDamien J. DownesParesh VyasJim R. HughesThomas A. MilneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Godfrey Nicholas T. Crump Ross Thorne I-Jun Lau Emmanouela Repapi Dimitra Dimou Alastair L. Smith Joe R. Harman Jelena M. Telenius A. Marieke Oudelaar Damien J. Downes Paresh Vyas Jim R. Hughes Thomas A. Milne DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
description	Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in MLL-AF4 leukemia cells.
format	article
author	Laura Godfrey Nicholas T. Crump Ross Thorne I-Jun Lau Emmanouela Repapi Dimitra Dimou Alastair L. Smith Joe R. Harman Jelena M. Telenius A. Marieke Oudelaar Damien J. Downes Paresh Vyas Jim R. Hughes Thomas A. Milne
author_facet	Laura Godfrey Nicholas T. Crump Ross Thorne I-Jun Lau Emmanouela Repapi Dimitra Dimou Alastair L. Smith Joe R. Harman Jelena M. Telenius A. Marieke Oudelaar Damien J. Downes Paresh Vyas Jim R. Hughes Thomas A. Milne
author_sort	Laura Godfrey
title	DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
title_short	DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
title_full	DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
title_fullStr	DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
title_full_unstemmed	DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
title_sort	dot1l inhibition reveals a distinct subset of enhancers dependent on h3k79 methylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4a9cce559524c16a138443251705752
work_keys_str_mv	AT lauragodfrey dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT nicholastcrump dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT rossthorne dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT ijunlau dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT emmanouelarepapi dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT dimitradimou dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT alastairlsmith dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT joerharman dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT jelenamtelenius dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT amariekeoudelaar dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT damienjdownes dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT pareshvyas dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT jimrhughes dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation AT thomasamilne dot1linhibitionrevealsadistinctsubsetofenhancersdependentonh3k79methylation
_version_	1718380586339401728

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

Ejemplares similares