PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

The role of PD-L1 expression on tumor-infiltrating immune cells in promoting tumor immune escape is not fully understood. Here, the authors show that PD-L1 expression by dendritic cells plays a crucial role in hindering anti-tumor T cell responses and is essential for the therapeutic efficacy of PD-...

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Autores principales:	Qi Peng, Xiangyan Qiu, Zihan Zhang, Silin Zhang, Yuanyuan Zhang, Yong Liang, Jingya Guo, Hua Peng, Mingyi Chen, Yang-Xin Fu, Haidong Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4ab035ca87340ce8581f2ec446042ea
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spelling	oai:doaj.org-article:e4ab035ca87340ce8581f2ec446042ea2021-12-02T17:26:56ZPD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade10.1038/s41467-020-18570-x2041-1723https://doaj.org/article/e4ab035ca87340ce8581f2ec446042ea2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18570-xhttps://doaj.org/toc/2041-1723The role of PD-L1 expression on tumor-infiltrating immune cells in promoting tumor immune escape is not fully understood. Here, the authors show that PD-L1 expression by dendritic cells plays a crucial role in hindering anti-tumor T cell responses and is essential for the therapeutic efficacy of PD-L1 blockade.Qi PengXiangyan QiuZihan ZhangSilin ZhangYuanyuan ZhangYong LiangJingya GuoHua PengMingyi ChenYang-Xin FuHaidong TangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Peng Xiangyan Qiu Zihan Zhang Silin Zhang Yuanyuan Zhang Yong Liang Jingya Guo Hua Peng Mingyi Chen Yang-Xin Fu Haidong Tang PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
description	The role of PD-L1 expression on tumor-infiltrating immune cells in promoting tumor immune escape is not fully understood. Here, the authors show that PD-L1 expression by dendritic cells plays a crucial role in hindering anti-tumor T cell responses and is essential for the therapeutic efficacy of PD-L1 blockade.
format	article
author	Qi Peng Xiangyan Qiu Zihan Zhang Silin Zhang Yuanyuan Zhang Yong Liang Jingya Guo Hua Peng Mingyi Chen Yang-Xin Fu Haidong Tang
author_facet	Qi Peng Xiangyan Qiu Zihan Zhang Silin Zhang Yuanyuan Zhang Yong Liang Jingya Guo Hua Peng Mingyi Chen Yang-Xin Fu Haidong Tang
author_sort	Qi Peng
title	PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
title_short	PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
title_full	PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
title_fullStr	PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
title_full_unstemmed	PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
title_sort	pd-l1 on dendritic cells attenuates t cell activation and regulates response to immune checkpoint blockade
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e4ab035ca87340ce8581f2ec446042ea
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PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

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