Comparison of PLA-Based Micelles and Microspheres as Carriers of Epothilone B and Rapamycin. The Effect of Delivery System and Polymer Composition on Drug Release and Cytotoxicity against MDA-MB-231 Breast Cancer Cells

Comparison of PLA-Based Micelles and Microspheres as Carriers of Epothilone B and Rapamycin. The Effect of Delivery System and Polymer Composition on Drug Release and Cytotoxicity against MDA-MB-231 Breast Cancer Cells

Co-delivery of epothilone B (EpoB) and rapamycin (Rap) increases cytotoxicity against various kinds of cancers. However, the current challenge is to develop a drug delivery system (DDS) for the simultaneous delivery and release of these two drugs. Additionally, it is important to understand the rele...

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Autores principales: Katarzyna Jelonek, Alicja Zajdel, Adam Wilczok, Bożena Kaczmarczyk, Monika Musiał-Kulik, Anna Hercog, Aleksander Foryś, Małgorzata Pastusiak, Janusz Kasperczyk
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
microspheres
micelles
PLA
PLA–PEG
controlled drug delivery system
breast cancer
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/e4abe9fdd13c44818142c4de5275a8a5
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