Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Transient oligomeric species of the amyloid-β peptide (Aβ42) have been identified as key pathogenic agents in Alzheimer’s disease. Here the authors find that the aminosterol trodusquemine enhances Aβ42 aggregation and suppresses Aβ42-induced toxicity by displacing oligomers from cell membranes....
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Nature Portfolio
2019
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oai:doaj.org-article:e4aca3eea6e44315b03de5b6488da79d2021-12-02T17:01:27ZTrodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes10.1038/s41467-018-07699-52041-1723https://doaj.org/article/e4aca3eea6e44315b03de5b6488da79d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07699-5https://doaj.org/toc/2041-1723Transient oligomeric species of the amyloid-β peptide (Aβ42) have been identified as key pathogenic agents in Alzheimer’s disease. Here the authors find that the aminosterol trodusquemine enhances Aβ42 aggregation and suppresses Aβ42-induced toxicity by displacing oligomers from cell membranes.Ryan LimbockerSean ChiaFrancesco S. RuggeriMichele PerniRoberta CascellaGabriella T. HellerGeorg MeislBenedetta ManniniJohnny HabchiThomas C. T. MichaelsPavan K. ChallaMinkoo AhnSamuel T. CasfordNilumi FernandoCatherine K. XuNina D. KlossSamuel I. A. CohenJanet R. KumitaCristina CecchiMichael ZasloffSara LinseTuomas P. J. KnowlesFabrizio ChitiMichele VendruscoloChristopher M. DobsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ryan Limbocker Sean Chia Francesco S. Ruggeri Michele Perni Roberta Cascella Gabriella T. Heller Georg Meisl Benedetta Mannini Johnny Habchi Thomas C. T. Michaels Pavan K. Challa Minkoo Ahn Samuel T. Casford Nilumi Fernando Catherine K. Xu Nina D. Kloss Samuel I. A. Cohen Janet R. Kumita Cristina Cecchi Michael Zasloff Sara Linse Tuomas P. J. Knowles Fabrizio Chiti Michele Vendruscolo Christopher M. Dobson Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes |
| description |
Transient oligomeric species of the amyloid-β peptide (Aβ42) have been identified as key pathogenic agents in Alzheimer’s disease. Here the authors find that the aminosterol trodusquemine enhances Aβ42 aggregation and suppresses Aβ42-induced toxicity by displacing oligomers from cell membranes. |
| format |
article |
| author |
Ryan Limbocker Sean Chia Francesco S. Ruggeri Michele Perni Roberta Cascella Gabriella T. Heller Georg Meisl Benedetta Mannini Johnny Habchi Thomas C. T. Michaels Pavan K. Challa Minkoo Ahn Samuel T. Casford Nilumi Fernando Catherine K. Xu Nina D. Kloss Samuel I. A. Cohen Janet R. Kumita Cristina Cecchi Michael Zasloff Sara Linse Tuomas P. J. Knowles Fabrizio Chiti Michele Vendruscolo Christopher M. Dobson |
| author_facet |
Ryan Limbocker Sean Chia Francesco S. Ruggeri Michele Perni Roberta Cascella Gabriella T. Heller Georg Meisl Benedetta Mannini Johnny Habchi Thomas C. T. Michaels Pavan K. Challa Minkoo Ahn Samuel T. Casford Nilumi Fernando Catherine K. Xu Nina D. Kloss Samuel I. A. Cohen Janet R. Kumita Cristina Cecchi Michael Zasloff Sara Linse Tuomas P. J. Knowles Fabrizio Chiti Michele Vendruscolo Christopher M. Dobson |
| author_sort |
Ryan Limbocker |
| title |
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes |
| title_short |
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes |
| title_full |
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes |
| title_fullStr |
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes |
| title_full_unstemmed |
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes |
| title_sort |
trodusquemine enhances aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/e4aca3eea6e44315b03de5b6488da79d |
| work_keys_str_mv |
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