Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.

Biomineralization templated by organic molecules to produce inorganic-organic nanocomposites is a fascinating example of nature using bottom-up strategies at nanoscale to accomplish highly ordered multifunctional materials. One such nanocomposite is bone, composed primarily of hydroxyapatite (HA) na...

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Autores principales:	Yuping Li, Conrado Aparicio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4acd311346d4080aea6891c904f4ccd
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spelling	oai:doaj.org-article:e4acd311346d4080aea6891c904f4ccd2021-11-18T08:54:14ZDiscerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.1932-620310.1371/journal.pone.0076782https://doaj.org/article/e4acd311346d4080aea6891c904f4ccd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086763/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Biomineralization templated by organic molecules to produce inorganic-organic nanocomposites is a fascinating example of nature using bottom-up strategies at nanoscale to accomplish highly ordered multifunctional materials. One such nanocomposite is bone, composed primarily of hydroxyapatite (HA) nanocrystals that are embedded within collagen fibrils with their c-axes arranged roughly parallel to the long axis of the fibrils. Here we discern the ultra-structure of biomimetic mineralized collagen fibrils (MCFs) as consisting of bundles of subfibrils with approximately 10 nm diameter; each one with an organic-inorganic core-shell structure. Through an amorphous calcium phosphate precursor phase the HA nanocrystals were specifically grown along the longitudinal direction of the collagen microfibrils and encapsulated them within the crystal lattice. They intercalated throughout the collagen fibrils such that the mineral phase surrounded the surface of collagen microfibrils forming an interdigitated network. It appears that this arrangement of collagen microfibrils in collagen fibrils is responsible for the observed ultrastructure. Such a subfibrillar nanostructure in MCFs was identified in both synthetic and natural bone, suggesting this is the basic building block of collagen-based hard tissues. Insights into the ultrastructure of mineralized collagen fibrils have the potential to advance our understanding on the biomineralization principles and the relationship between bone's structure and mechanical properties, including fracture toughness mechanisms. We anticipate that these principles from biological systems can be applied to the rational design of new nanocomposites with improved performance.Yuping LiConrado AparicioPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e76782 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuping Li Conrado Aparicio Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.
description	Biomineralization templated by organic molecules to produce inorganic-organic nanocomposites is a fascinating example of nature using bottom-up strategies at nanoscale to accomplish highly ordered multifunctional materials. One such nanocomposite is bone, composed primarily of hydroxyapatite (HA) nanocrystals that are embedded within collagen fibrils with their c-axes arranged roughly parallel to the long axis of the fibrils. Here we discern the ultra-structure of biomimetic mineralized collagen fibrils (MCFs) as consisting of bundles of subfibrils with approximately 10 nm diameter; each one with an organic-inorganic core-shell structure. Through an amorphous calcium phosphate precursor phase the HA nanocrystals were specifically grown along the longitudinal direction of the collagen microfibrils and encapsulated them within the crystal lattice. They intercalated throughout the collagen fibrils such that the mineral phase surrounded the surface of collagen microfibrils forming an interdigitated network. It appears that this arrangement of collagen microfibrils in collagen fibrils is responsible for the observed ultrastructure. Such a subfibrillar nanostructure in MCFs was identified in both synthetic and natural bone, suggesting this is the basic building block of collagen-based hard tissues. Insights into the ultrastructure of mineralized collagen fibrils have the potential to advance our understanding on the biomineralization principles and the relationship between bone's structure and mechanical properties, including fracture toughness mechanisms. We anticipate that these principles from biological systems can be applied to the rational design of new nanocomposites with improved performance.
format	article
author	Yuping Li Conrado Aparicio
author_facet	Yuping Li Conrado Aparicio
author_sort	Yuping Li
title	Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.
title_short	Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.
title_full	Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.
title_fullStr	Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.
title_full_unstemmed	Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.
title_sort	discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e4acd311346d4080aea6891c904f4ccd
work_keys_str_mv	AT yupingli discerningthesubfibrillarstructureofmineralizedcollagenfibrilsamodelfortheultrastructureofbone AT conradoaparicio discerningthesubfibrillarstructureofmineralizedcollagenfibrilsamodelfortheultrastructureofbone
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Discerning the subfibrillar structure of mineralized collagen fibrils: a model for the ultrastructure of bone.

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