Windows of opportunity for Ebola virus infection treatment and vaccination

Abstract Ebola virus (EBOV) infection causes a high death toll, killing a high proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV infection are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Van Kinh Nguyen, Esteban A. Hernandez-Vargas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4ad7b11c75e48b687ec741e244a95fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e4ad7b11c75e48b687ec741e244a95fe
record_format	dspace
spelling	oai:doaj.org-article:e4ad7b11c75e48b687ec741e244a95fe2021-12-02T11:52:32ZWindows of opportunity for Ebola virus infection treatment and vaccination10.1038/s41598-017-08884-02045-2322https://doaj.org/article/e4ad7b11c75e48b687ec741e244a95fe2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08884-0https://doaj.org/toc/2045-2322Abstract Ebola virus (EBOV) infection causes a high death toll, killing a high proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV infection are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models become valuable resources to explore potential controlling strategies. In this paper, we employed experimental data of EBOV-infected nonhuman primates (NHPs) to construct a mathematical framework for determining windows of opportunity for treatment and vaccination. Considering a prophylactic vaccine based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (rVSV-EBOV), vaccination could be protective if a subject is vaccinated during a period from one week to four months before infection. For the case of a therapeutic vaccine based on monoclonal antibodies (mAbs), a single dose might resolve the invasive EBOV replication even if it was administrated as late as four days after infection. Our mathematical models can be used as building blocks for evaluating therapeutic and vaccine modalities as well as for evaluating public health intervention strategies in outbreaks. Future laboratory experiments will help to validate and refine the estimates of the windows of opportunity proposed here.Van Kinh NguyenEsteban A. Hernandez-VargasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Van Kinh Nguyen Esteban A. Hernandez-Vargas Windows of opportunity for Ebola virus infection treatment and vaccination
description	Abstract Ebola virus (EBOV) infection causes a high death toll, killing a high proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV infection are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models become valuable resources to explore potential controlling strategies. In this paper, we employed experimental data of EBOV-infected nonhuman primates (NHPs) to construct a mathematical framework for determining windows of opportunity for treatment and vaccination. Considering a prophylactic vaccine based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (rVSV-EBOV), vaccination could be protective if a subject is vaccinated during a period from one week to four months before infection. For the case of a therapeutic vaccine based on monoclonal antibodies (mAbs), a single dose might resolve the invasive EBOV replication even if it was administrated as late as four days after infection. Our mathematical models can be used as building blocks for evaluating therapeutic and vaccine modalities as well as for evaluating public health intervention strategies in outbreaks. Future laboratory experiments will help to validate and refine the estimates of the windows of opportunity proposed here.
format	article
author	Van Kinh Nguyen Esteban A. Hernandez-Vargas
author_facet	Van Kinh Nguyen Esteban A. Hernandez-Vargas
author_sort	Van Kinh Nguyen
title	Windows of opportunity for Ebola virus infection treatment and vaccination
title_short	Windows of opportunity for Ebola virus infection treatment and vaccination
title_full	Windows of opportunity for Ebola virus infection treatment and vaccination
title_fullStr	Windows of opportunity for Ebola virus infection treatment and vaccination
title_full_unstemmed	Windows of opportunity for Ebola virus infection treatment and vaccination
title_sort	windows of opportunity for ebola virus infection treatment and vaccination
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e4ad7b11c75e48b687ec741e244a95fe
work_keys_str_mv	AT vankinhnguyen windowsofopportunityforebolavirusinfectiontreatmentandvaccination AT estebanahernandezvargas windowsofopportunityforebolavirusinfectiontreatmentandvaccination
_version_	1718395017065660416

Windows of opportunity for Ebola virus infection treatment and vaccination

Ejemplares similares