Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.

In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According...

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Autores principales:	Kristof Molnar, Constantinos Voniatis, Daniella Feher, Gyorgyi Szabo, Rita Varga, Lilla Reiniger, David Juriga, Zoltan Kiss, Eniko Krisch, Gyorgy Weber, Andrea Ferencz, Gabor Varga, Miklos Zrinyi, Krisztina S Nagy, Angela Jedlovszky-Hajdu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4aecbca65b74606abb393874f788473
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spelling	oai:doaj.org-article:e4aecbca65b74606abb393874f7884732021-12-02T20:18:11ZPoly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.1932-620310.1371/journal.pone.0254843https://doaj.org/article/e4aecbca65b74606abb393874f7884732021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254843https://doaj.org/toc/1932-6203In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3rd day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days.Kristof MolnarConstantinos VoniatisDaniella FeherGyorgyi SzaboRita VargaLilla ReinigerDavid JurigaZoltan KissEniko KrischGyorgy WeberAndrea FerenczGabor VargaMiklos ZrinyiKrisztina S NagyAngela Jedlovszky-HajduPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254843 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristof Molnar Constantinos Voniatis Daniella Feher Gyorgyi Szabo Rita Varga Lilla Reiniger David Juriga Zoltan Kiss Eniko Krisch Gyorgy Weber Andrea Ferencz Gabor Varga Miklos Zrinyi Krisztina S Nagy Angela Jedlovszky-Hajdu Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.
description	In this work two types of biodegradable polysuccinimide-based, electrospun fibrous membranes are presented. One contains disulfide bonds exhibiting a shorter (3 days) in vivo biodegradation time, while the other one has alkyl crosslinks and a longer biodegradation time (more than 7 days). According to the mechanical measurements, the tensile strength of the membranes is comparable to those of soft the connective tissues and visceral tissues. Furthermore, the suture retention test suggests, that the membranes would withstand surgical handling and in vivo fixation. The in vivo biocompatibility study demonstrates how membranes undergo in vivo hydrolysis and by the 3rd day they become poly(aspartic acid) fibrous membranes, which can be then enzymatically degraded. After one week, the disulfide crosslinked membranes almost completely degrade, while the alkyl-chain crosslinked ones mildly lose their integrity as the surrounding tissue invades them. Histopathology revealed mild acute inflammation, which diminished to a minimal level after seven days.
format	article
author	Kristof Molnar Constantinos Voniatis Daniella Feher Gyorgyi Szabo Rita Varga Lilla Reiniger David Juriga Zoltan Kiss Eniko Krisch Gyorgy Weber Andrea Ferencz Gabor Varga Miklos Zrinyi Krisztina S Nagy Angela Jedlovszky-Hajdu
author_facet	Kristof Molnar Constantinos Voniatis Daniella Feher Gyorgyi Szabo Rita Varga Lilla Reiniger David Juriga Zoltan Kiss Eniko Krisch Gyorgy Weber Andrea Ferencz Gabor Varga Miklos Zrinyi Krisztina S Nagy Angela Jedlovszky-Hajdu
author_sort	Kristof Molnar
title	Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.
title_short	Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.
title_full	Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.
title_fullStr	Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.
title_full_unstemmed	Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.
title_sort	poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e4aecbca65b74606abb393874f788473
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Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation.

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