Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica

Introduction: Seaweeds are valuable resources for the discovery of efficient and safe drugs for pain treatment. In the present investigation, we evaluated the antinociceptive and anti-inflammatory properties of, methanolic extract of Laurencia caspica, a red algae, in mice models. Methods: The anal...

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Autores principales:	Katayoon Karimzadeh, Mahdiyeh Ramzanpoor, Shadi Keihankhadiv
Formato:	article
Lenguaje:	EN
Publicado:	Zabol University of Medical sciences 2020
Materias:	red algae laurencia caspica anti-inflammatory antinociceptive Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e4b064962d4b4a478173588f7c1474f0
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spelling	oai:doaj.org-article:e4b064962d4b4a478173588f7c1474f02021-11-17T09:54:24ZAntinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica2476-664X10.34172/ijbsm.2020.11https://doaj.org/article/e4b064962d4b4a478173588f7c1474f02020-06-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-13390https://doaj.org/toc/2476-664XIntroduction: Seaweeds are valuable resources for the discovery of efficient and safe drugs for pain treatment. In the present investigation, we evaluated the antinociceptive and anti-inflammatory properties of, methanolic extract of Laurencia caspica, a red algae, in mice models. Methods: The analgesic effect of methanolic extract of L. caspica was assessed by hot-plate and acetic acid-induced writhing tests in male Swiss albino mice (weight = 20-25 g). The anti-inflammatory activity of methanolic extract of L. caspica was also evaluated by formalin-induced ear edema and xylene-induced paw edema tests. Results: The total flavonoid content of the extract was estimated as 0.0537 mg quercetin/g extract. Both first and second phases of the nociception were significantly inhibited at a dose of 120 mg/kg of methanolic extract of L. caspica. The observed anti-inflammatory effect was dose-dependent. Acetic acid-induced writhing test and hot plate test showed that the extract significantly reduced pain in all evaluated doses (15, 30, 60, and 120 mg/kg). The antinociceptive activity of the methanolic extract was significantly reduced by naloxone (4 mg/kg). Moreover, the extract significantly reduced paw edema at the dose of 120 mg/kg in all the animals. Conclusion: Methanolic extract of L. caspica exhibited central analgesic effect, as well as anti-inflammatory activity probably due to the presence of constituents like flavonoids and triterpenoids.Katayoon KarimzadehMahdiyeh RamzanpoorShadi KeihankhadivZabol University of Medical sciencesarticlered algae laurencia caspica anti-inflammatory antinociceptive Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 5, Iss 2, Pp 54-60 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	red algae laurencia caspica anti-inflammatory antinociceptive Medicine (General) R5-920
spellingShingle	red algae laurencia caspica anti-inflammatory antinociceptive Medicine (General) R5-920 Katayoon Karimzadeh Mahdiyeh Ramzanpoor Shadi Keihankhadiv Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica
description	Introduction: Seaweeds are valuable resources for the discovery of efficient and safe drugs for pain treatment. In the present investigation, we evaluated the antinociceptive and anti-inflammatory properties of, methanolic extract of Laurencia caspica, a red algae, in mice models. Methods: The analgesic effect of methanolic extract of L. caspica was assessed by hot-plate and acetic acid-induced writhing tests in male Swiss albino mice (weight = 20-25 g). The anti-inflammatory activity of methanolic extract of L. caspica was also evaluated by formalin-induced ear edema and xylene-induced paw edema tests. Results: The total flavonoid content of the extract was estimated as 0.0537 mg quercetin/g extract. Both first and second phases of the nociception were significantly inhibited at a dose of 120 mg/kg of methanolic extract of L. caspica. The observed anti-inflammatory effect was dose-dependent. Acetic acid-induced writhing test and hot plate test showed that the extract significantly reduced pain in all evaluated doses (15, 30, 60, and 120 mg/kg). The antinociceptive activity of the methanolic extract was significantly reduced by naloxone (4 mg/kg). Moreover, the extract significantly reduced paw edema at the dose of 120 mg/kg in all the animals. Conclusion: Methanolic extract of L. caspica exhibited central analgesic effect, as well as anti-inflammatory activity probably due to the presence of constituents like flavonoids and triterpenoids.
format	article
author	Katayoon Karimzadeh Mahdiyeh Ramzanpoor Shadi Keihankhadiv
author_facet	Katayoon Karimzadeh Mahdiyeh Ramzanpoor Shadi Keihankhadiv
author_sort	Katayoon Karimzadeh
title	Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica
title_short	Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica
title_full	Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica
title_fullStr	Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica
title_full_unstemmed	Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica
title_sort	antinociceptive and anti-inflammatory effects of methanolic extract of laurencia caspica
publisher	Zabol University of Medical sciences
publishDate	2020
url	https://doaj.org/article/e4b064962d4b4a478173588f7c1474f0
work_keys_str_mv	AT katayoonkarimzadeh antinociceptiveandantiinflammatoryeffectsofmethanolicextractoflaurenciacaspica AT mahdiyehramzanpoor antinociceptiveandantiinflammatoryeffectsofmethanolicextractoflaurenciacaspica AT shadikeihankhadiv antinociceptiveandantiinflammatoryeffectsofmethanolicextractoflaurenciacaspica
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Antinociceptive and Anti-inflammatory Effects of Methanolic Extract of Laurencia caspica

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