MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)

This review discusses the data of new researches on the functional purpose of sleep and its stages, and its role in the development of pathological conditions. The main modern hypotheses and concepts about a role of slow sleep and REM-sleep (rapid eye movement) are interpreted. The visceral theory o...

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Autores principales: I. M. Madaeva, O. N. Berdina
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Lenguaje:RU
Publicado: Scientific Сentre for Family Health and Human Reproduction Problems 2017
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Acceso en línea:https://doaj.org/article/e4b13be1b6554555bc34bd8a0dfcb063
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spelling oai:doaj.org-article:e4b13be1b6554555bc34bd8a0dfcb0632021-11-23T06:14:38ZMODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)2541-94202587-959610.12737/article_59fad513a63772.41901536https://doaj.org/article/e4b13be1b6554555bc34bd8a0dfcb0632017-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/411https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This review discusses the data of new researches on the functional purpose of sleep and its stages, and its role in the development of pathological conditions. The main modern hypotheses and concepts about a role of slow sleep and REM-sleep (rapid eye movement) are interpreted. The visceral theory of slow sleep as an activator of restorative processes in the brain and manager of internal organs functions is described. A brain "drainage" function of slow sleep is known. Recent studies suggest sleep-wake disturbances, for example, obstructive apnea syndrome, may influence Alzheimer's disease (AD) onset and progression. Possible mechanisms such asfunctional disorders of brain lymphatic system during slow sleep and the extracellular accumulation of the amyloid-ß (Aß) peptide underlying the relationship between the sleep-wake disturbances and AD are described. The role of REM-sleep in the formation of the central nervous system in the early postnatal period and the performance of the function of mental adaptation are discussed. In this article, we presented data about the role both of neurotransmitters and neuropeptides in the regulation of sleep-wake cycle and the maintenance of wakefulness and REM-sleep. The possible new approach to the forecasting of cognitive and emotional-affective disorders in sleep disturbances is substantiated from the perspective of modern neuroscience and sleep neurophysiology still in childhood is justified.I. M. MadaevaO. N. BerdinaScientific Сentre for Family Health and Human Reproduction Problemsarticle«медленный сон»«быстрый сон»b-амилоидsleep-wake cycleslow sleeprem-sleeprestoring sleep functionhypothesis of “drainage” sleep functionamyloid-b peptidealzheimer’s diseaseScienceQRUActa Biomedica Scientifica, Vol 2, Iss 4, Pp 48-52 (2017)
institution DOAJ
collection DOAJ
language RU
topic «медленный сон»
«быстрый сон»
b-амилоид
sleep-wake cycle
slow sleep
rem-sleep
restoring sleep function
hypothesis of “drainage” sleep function
amyloid-b peptide
alzheimer’s disease
Science
Q
spellingShingle «медленный сон»
«быстрый сон»
b-амилоид
sleep-wake cycle
slow sleep
rem-sleep
restoring sleep function
hypothesis of “drainage” sleep function
amyloid-b peptide
alzheimer’s disease
Science
Q
I. M. Madaeva
O. N. Berdina
MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)
description This review discusses the data of new researches on the functional purpose of sleep and its stages, and its role in the development of pathological conditions. The main modern hypotheses and concepts about a role of slow sleep and REM-sleep (rapid eye movement) are interpreted. The visceral theory of slow sleep as an activator of restorative processes in the brain and manager of internal organs functions is described. A brain "drainage" function of slow sleep is known. Recent studies suggest sleep-wake disturbances, for example, obstructive apnea syndrome, may influence Alzheimer's disease (AD) onset and progression. Possible mechanisms such asfunctional disorders of brain lymphatic system during slow sleep and the extracellular accumulation of the amyloid-ß (Aß) peptide underlying the relationship between the sleep-wake disturbances and AD are described. The role of REM-sleep in the formation of the central nervous system in the early postnatal period and the performance of the function of mental adaptation are discussed. In this article, we presented data about the role both of neurotransmitters and neuropeptides in the regulation of sleep-wake cycle and the maintenance of wakefulness and REM-sleep. The possible new approach to the forecasting of cognitive and emotional-affective disorders in sleep disturbances is substantiated from the perspective of modern neuroscience and sleep neurophysiology still in childhood is justified.
format article
author I. M. Madaeva
O. N. Berdina
author_facet I. M. Madaeva
O. N. Berdina
author_sort I. M. Madaeva
title MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)
title_short MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)
title_full MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)
title_fullStr MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)
title_full_unstemmed MODERN IDEAS OF “SLOW SLEEP” AND “REM-SLEEP” AND THEIR ROLE IN PATHOGENESIS OF ALZHEIMER’S DISEASE (REVIEW OF LITERATURE)
title_sort modern ideas of “slow sleep” and “rem-sleep” and their role in pathogenesis of alzheimer’s disease (review of literature)
publisher Scientific Сentre for Family Health and Human Reproduction Problems
publishDate 2017
url https://doaj.org/article/e4b13be1b6554555bc34bd8a0dfcb063
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AT onberdina modernideasofslowsleepandremsleepandtheirroleinpathogenesisofalzheimersdiseasereviewofliterature
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