Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction

An imbalance between cell growth and bioproduction of engineered microbes often reduces production efficiency. Here, the authors report genetic code expansion-based cell growth and biosynthesis balance engineering to achieve high levels production of N-acetylglucosamine in E. coli and N-acetylneuram...

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Autores principales:	Rongzhen Tian, Yanfeng Liu, Yanting Cao, Zhongjie Zhang, Jianghua Li, Long Liu, Guocheng Du, Jian Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4b1b57ed51e46f89bf4ce6ab7559907
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spelling	oai:doaj.org-article:e4b1b57ed51e46f89bf4ce6ab75599072021-12-02T19:16:24ZTitrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction10.1038/s41467-020-18960-12041-1723https://doaj.org/article/e4b1b57ed51e46f89bf4ce6ab75599072020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18960-1https://doaj.org/toc/2041-1723An imbalance between cell growth and bioproduction of engineered microbes often reduces production efficiency. Here, the authors report genetic code expansion-based cell growth and biosynthesis balance engineering to achieve high levels production of N-acetylglucosamine in E. coli and N-acetylneuraminic acid in B. subtilis.Rongzhen TianYanfeng LiuYanting CaoZhongjie ZhangJianghua LiLong LiuGuocheng DuJian ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rongzhen Tian Yanfeng Liu Yanting Cao Zhongjie Zhang Jianghua Li Long Liu Guocheng Du Jian Chen Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction
description	An imbalance between cell growth and bioproduction of engineered microbes often reduces production efficiency. Here, the authors report genetic code expansion-based cell growth and biosynthesis balance engineering to achieve high levels production of N-acetylglucosamine in E. coli and N-acetylneuraminic acid in B. subtilis.
format	article
author	Rongzhen Tian Yanfeng Liu Yanting Cao Zhongjie Zhang Jianghua Li Long Liu Guocheng Du Jian Chen
author_facet	Rongzhen Tian Yanfeng Liu Yanting Cao Zhongjie Zhang Jianghua Li Long Liu Guocheng Du Jian Chen
author_sort	Rongzhen Tian
title	Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction
title_short	Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction
title_full	Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction
title_fullStr	Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction
title_full_unstemmed	Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction
title_sort	titrating bacterial growth and chemical biosynthesis for efficient n-acetylglucosamine and n-acetylneuraminic acid bioproduction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e4b1b57ed51e46f89bf4ce6ab7559907
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Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction

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