The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.

<h4>Background</h4>The burden and contribution of modifiable risk factors of stroke in Ethiopia are unclear. Knowledge about this burden and modifying risk factors is pivotal for establishing stroke prevention strategies. In recent decades, the issue of lifestyle and behavioral modificat...

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Autores principales:	Teshager Weldegiorgis Abate, Balew Zeleke, Ashenafi Genanew, Bidiru Weldegiorgis Abate
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4b7350979ae45e8bfc4f04dad69c959
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spelling	oai:doaj.org-article:e4b7350979ae45e8bfc4f04dad69c9592021-12-02T20:04:35ZThe burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.1932-620310.1371/journal.pone.0259244https://doaj.org/article/e4b7350979ae45e8bfc4f04dad69c9592021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259244https://doaj.org/toc/1932-6203<h4>Background</h4>The burden and contribution of modifiable risk factors of stroke in Ethiopia are unclear. Knowledge about this burden and modifying risk factors is pivotal for establishing stroke prevention strategies. In recent decades, the issue of lifestyle and behavioral modification is a key to improve the quality of life. The modifiable risk factors are an importance as intervention strategies aimed at reducing these factors can subsequently reduce the risk of stroke. So far, many primary studies were conducted to estimate the burden of stroke and modifiable risk factors in Ethiopia. However, the lack of a nationwide study that determines the overall pooled estimation of burden and modifiable risk factors of stroke is a research gap.<h4>Methods</h4>To conduct this systemic review and meta-analysis, we are following the PRISMA checklist. Three authors searched and extracted the data from the CINAHL (EBSCO), MEDLINE (via Ovid), PubMed, EMcare, African Journals Online (AJOL), and Google scholar. The quality of the primary study was assessed using the Newcastle-Ottawa Scale (NOS) by two independent reviewers. The primary studies with low and moderate risk of bias were included in the final analysis. The authors presented the pooled estimated burden of stroke and its modifiable risk factors. The registered protocol number in PROSPERO was CRD42020221906.<h4>Results</h4>In this study, the pooled burden of hemorrhagic and ischemic stroke were 46.42% (95%CI: 41.82-51.53; I2 = 91.6%) and 51.40% (95%CI: 46.97-55.82; I2 = 85.5%) respectively. The overall magnitude of modifiable risk factor of hypertension, alcohol consumption and dyslipidemia among stroke patients were 49% (95%CI: 43.59, 54.41), 24.96% (95CI%:15.01, 34.90), and 20.99% (95%CI: 11.10, 30.88), respectively. The least proportion of stroke recovery was in the Oromia region (67.38 (95%CI: 41.60-93.17; I2 = 98.1%). Farther more, the proportion of stroke recovery was decreased after 2017 (70.50 (56.80-84.20).<h4>Conclusions</h4>In our study, more than 90% of stroke patients had one or more modifiable risk factors. All identified modifiable stroke risk factors are major public health issues in Ethiopia. Therefore, strategy is designed for stroke prevention to decrease stroke burden through targeted modification of a single risk factor, or a cluster of multiple risk factors, used on a population, community, or individual level.Teshager Weldegiorgis AbateBalew ZelekeAshenafi GenanewBidiru Weldegiorgis AbatePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259244 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Teshager Weldegiorgis Abate Balew Zeleke Ashenafi Genanew Bidiru Weldegiorgis Abate The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.
description	<h4>Background</h4>The burden and contribution of modifiable risk factors of stroke in Ethiopia are unclear. Knowledge about this burden and modifying risk factors is pivotal for establishing stroke prevention strategies. In recent decades, the issue of lifestyle and behavioral modification is a key to improve the quality of life. The modifiable risk factors are an importance as intervention strategies aimed at reducing these factors can subsequently reduce the risk of stroke. So far, many primary studies were conducted to estimate the burden of stroke and modifiable risk factors in Ethiopia. However, the lack of a nationwide study that determines the overall pooled estimation of burden and modifiable risk factors of stroke is a research gap.<h4>Methods</h4>To conduct this systemic review and meta-analysis, we are following the PRISMA checklist. Three authors searched and extracted the data from the CINAHL (EBSCO), MEDLINE (via Ovid), PubMed, EMcare, African Journals Online (AJOL), and Google scholar. The quality of the primary study was assessed using the Newcastle-Ottawa Scale (NOS) by two independent reviewers. The primary studies with low and moderate risk of bias were included in the final analysis. The authors presented the pooled estimated burden of stroke and its modifiable risk factors. The registered protocol number in PROSPERO was CRD42020221906.<h4>Results</h4>In this study, the pooled burden of hemorrhagic and ischemic stroke were 46.42% (95%CI: 41.82-51.53; I2 = 91.6%) and 51.40% (95%CI: 46.97-55.82; I2 = 85.5%) respectively. The overall magnitude of modifiable risk factor of hypertension, alcohol consumption and dyslipidemia among stroke patients were 49% (95%CI: 43.59, 54.41), 24.96% (95CI%:15.01, 34.90), and 20.99% (95%CI: 11.10, 30.88), respectively. The least proportion of stroke recovery was in the Oromia region (67.38 (95%CI: 41.60-93.17; I2 = 98.1%). Farther more, the proportion of stroke recovery was decreased after 2017 (70.50 (56.80-84.20).<h4>Conclusions</h4>In our study, more than 90% of stroke patients had one or more modifiable risk factors. All identified modifiable stroke risk factors are major public health issues in Ethiopia. Therefore, strategy is designed for stroke prevention to decrease stroke burden through targeted modification of a single risk factor, or a cluster of multiple risk factors, used on a population, community, or individual level.
format	article
author	Teshager Weldegiorgis Abate Balew Zeleke Ashenafi Genanew Bidiru Weldegiorgis Abate
author_facet	Teshager Weldegiorgis Abate Balew Zeleke Ashenafi Genanew Bidiru Weldegiorgis Abate
author_sort	Teshager Weldegiorgis Abate
title	The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.
title_short	The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.
title_full	The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.
title_fullStr	The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.
title_full_unstemmed	The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.
title_sort	burden of stroke and modifiable risk factors in ethiopia: a systemic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e4b7350979ae45e8bfc4f04dad69c959
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The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis.

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