Update on schizophrenia and bipolar disorder: focus on cariprazine

Rona Jeannie Roberts,1 Lillian Jan Findlay,2 Peggy L El-Mallakh,2 Rif S El-Mallakh1 1Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, 2School of Nursing, University of Kentucky, Lexington, KY, USA Abstract:...

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Autores principales:	Roberts RJ, Findlay LJ, El-Mallakh PL, El-Mallakh RS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	cariprazine dopamine D3 receptor dopamine D2 receptor bipolar disorder mania bipolar depression schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e4b83a0205b74b39aca69d18d59e7c14
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spelling	oai:doaj.org-article:e4b83a0205b74b39aca69d18d59e7c142021-12-02T02:13:14ZUpdate on schizophrenia and bipolar disorder: focus on cariprazine1178-2021https://doaj.org/article/e4b83a0205b74b39aca69d18d59e7c142016-07-01T00:00:00Zhttps://www.dovepress.com/update-on-schizophrenia-and-bipolar-disorder-focus-on-cariprazine-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Rona Jeannie Roberts,1 Lillian Jan Findlay,2 Peggy L El-Mallakh,2 Rif S El-Mallakh1 1Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, 2School of Nursing, University of Kentucky, Lexington, KY, USA Abstract: Schizophrenia and bipolar disorder are severe psychiatric disorders that are frequently associated with persistent symptoms and significant dysfunction. While there are a multitude of psychopharmacologic agents are available for treatment of these illnesses, suboptimal response and significant adverse consequences limit their utility. Cariprazine is a new, novel antipsychotic medication with dopamine D2 and D3 partial agonist effects. Its safety and efficacy have been investigated in acute psychosis of schizophrenia, bipolar mania, bipolar depression, and unipolar depression. Efficacy has been demonstrated in schizophrenia and mania. It is unclear if cariprazine is effective in depression associated with unipolar or bipolar illness. Adverse consequences include extrapyramidal symptoms including akathisia, and various gastrointestinal symptoms. The US Food and Drug Administration (FDA) has recently approved cariprazine. This review will provide clinicians with basic information regarding the research program of cariprazine. Keywords: cariprazine, dopamine D3 receptor, dopamine D2 receptor, bipolar disorder, mania, bipolar depression, schizophreniaRoberts RJFindlay LJEl-Mallakh PLEl-Mallakh RSDove Medical Pressarticlecariprazinedopamine D3 receptordopamine D2 receptorbipolar disordermaniabipolar depressionschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1837-1842 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	cariprazine dopamine D3 receptor dopamine D2 receptor bipolar disorder mania bipolar depression schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	cariprazine dopamine D3 receptor dopamine D2 receptor bipolar disorder mania bipolar depression schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Roberts RJ Findlay LJ El-Mallakh PL El-Mallakh RS Update on schizophrenia and bipolar disorder: focus on cariprazine
description	Rona Jeannie Roberts,1 Lillian Jan Findlay,2 Peggy L El-Mallakh,2 Rif S El-Mallakh1 1Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, 2School of Nursing, University of Kentucky, Lexington, KY, USA Abstract: Schizophrenia and bipolar disorder are severe psychiatric disorders that are frequently associated with persistent symptoms and significant dysfunction. While there are a multitude of psychopharmacologic agents are available for treatment of these illnesses, suboptimal response and significant adverse consequences limit their utility. Cariprazine is a new, novel antipsychotic medication with dopamine D2 and D3 partial agonist effects. Its safety and efficacy have been investigated in acute psychosis of schizophrenia, bipolar mania, bipolar depression, and unipolar depression. Efficacy has been demonstrated in schizophrenia and mania. It is unclear if cariprazine is effective in depression associated with unipolar or bipolar illness. Adverse consequences include extrapyramidal symptoms including akathisia, and various gastrointestinal symptoms. The US Food and Drug Administration (FDA) has recently approved cariprazine. This review will provide clinicians with basic information regarding the research program of cariprazine. Keywords: cariprazine, dopamine D3 receptor, dopamine D2 receptor, bipolar disorder, mania, bipolar depression, schizophrenia
format	article
author	Roberts RJ Findlay LJ El-Mallakh PL El-Mallakh RS
author_facet	Roberts RJ Findlay LJ El-Mallakh PL El-Mallakh RS
author_sort	Roberts RJ
title	Update on schizophrenia and bipolar disorder: focus on cariprazine
title_short	Update on schizophrenia and bipolar disorder: focus on cariprazine
title_full	Update on schizophrenia and bipolar disorder: focus on cariprazine
title_fullStr	Update on schizophrenia and bipolar disorder: focus on cariprazine
title_full_unstemmed	Update on schizophrenia and bipolar disorder: focus on cariprazine
title_sort	update on schizophrenia and bipolar disorder: focus on cariprazine
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/e4b83a0205b74b39aca69d18d59e7c14
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Update on schizophrenia and bipolar disorder: focus on cariprazine

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