Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases

Gynecological illness accounts for around 4.5% of the global disease burden, which is higher than other key global health concerns such as malaria (1.04%), TB (1.9%), ischemic heart disease (2.2%), and maternal disorders (3.5%). Gynecological conditions in women of reproductive age are linked to bot...

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Autores principales:	Yasmin Begum, Anuradha Pandit, Snehasikta Swarnakar
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	inflammation gynecological cancer matrix metalloproteinase (MMP) A disintegrin and metalloproteinase (ADAM) A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS) metastasis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e4be654a16f8428ca2673b0d5a0c7959
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spelling	oai:doaj.org-article:e4be654a16f8428ca2673b0d5a0c79592021-12-01T13:32:17ZInsights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases2296-634X10.3389/fcell.2021.780510https://doaj.org/article/e4be654a16f8428ca2673b0d5a0c79592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.780510/fullhttps://doaj.org/toc/2296-634XGynecological illness accounts for around 4.5% of the global disease burden, which is higher than other key global health concerns such as malaria (1.04%), TB (1.9%), ischemic heart disease (2.2%), and maternal disorders (3.5%). Gynecological conditions in women of reproductive age are linked to both in terms of diagnosis and treatment, especially in low-income economies, which poses a serious social problem. A greater understanding of health promotion and illness management can help to prevent diseases in gynecology. Due to the lack of established biomarkers, the identification of gynecological diseases, including malignancies, has proven to be challenging in most situations, and histological exams remain the gold standard. Metalloproteinases (MMPs, ADAMs, ADAMTSs) and their endogenous inhibitors (TIMPs) modulate the protease-dependent bioavailability of local niche components (e.g., growth factors), matrix turnover, and cellular interactions to govern specific physical and biochemical characteristics of the environment. Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM), and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that contribute significantly to the disintegration of extracellular matrix proteins and shedding of membrane-bound receptor molecules in several diseases, including arthritis. MMPs are noteworthy genes associated with cancer development, functional angiogenesis, invasion, metastasis, and immune surveillance evasion. These genes are often elevated in cancer and multiple benign gynecological disorders like endometriosis, according to research. Migration through the extracellular matrix, which involves proteolytic activity, is an essential step in tumor cell extravasation and metastasis. However, none of the MMPs’ expression patterns, as well as their diagnostic and prognostic potential, have been studied in a pan-cancer context. The latter plays a very important role in cell signaling and might be used as a cancer treatment target. ADAMs are implicated in tumor cell proliferation, angiogenesis, and metastasis. This review will focus on the contribution of the aforementioned metalloproteinases in regulating gynecological disorders and their subsequent manipulation for therapeutic intervention.Yasmin BegumAnuradha PanditSnehasikta SwarnakarFrontiers Media S.A.articleinflammationgynecological cancermatrix metalloproteinase (MMP)A disintegrin and metalloproteinase (ADAM)A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS)metastasisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammation gynecological cancer matrix metalloproteinase (MMP) A disintegrin and metalloproteinase (ADAM) A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS) metastasis Biology (General) QH301-705.5
spellingShingle	inflammation gynecological cancer matrix metalloproteinase (MMP) A disintegrin and metalloproteinase (ADAM) A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS) metastasis Biology (General) QH301-705.5 Yasmin Begum Anuradha Pandit Snehasikta Swarnakar Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases
description	Gynecological illness accounts for around 4.5% of the global disease burden, which is higher than other key global health concerns such as malaria (1.04%), TB (1.9%), ischemic heart disease (2.2%), and maternal disorders (3.5%). Gynecological conditions in women of reproductive age are linked to both in terms of diagnosis and treatment, especially in low-income economies, which poses a serious social problem. A greater understanding of health promotion and illness management can help to prevent diseases in gynecology. Due to the lack of established biomarkers, the identification of gynecological diseases, including malignancies, has proven to be challenging in most situations, and histological exams remain the gold standard. Metalloproteinases (MMPs, ADAMs, ADAMTSs) and their endogenous inhibitors (TIMPs) modulate the protease-dependent bioavailability of local niche components (e.g., growth factors), matrix turnover, and cellular interactions to govern specific physical and biochemical characteristics of the environment. Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM), and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that contribute significantly to the disintegration of extracellular matrix proteins and shedding of membrane-bound receptor molecules in several diseases, including arthritis. MMPs are noteworthy genes associated with cancer development, functional angiogenesis, invasion, metastasis, and immune surveillance evasion. These genes are often elevated in cancer and multiple benign gynecological disorders like endometriosis, according to research. Migration through the extracellular matrix, which involves proteolytic activity, is an essential step in tumor cell extravasation and metastasis. However, none of the MMPs’ expression patterns, as well as their diagnostic and prognostic potential, have been studied in a pan-cancer context. The latter plays a very important role in cell signaling and might be used as a cancer treatment target. ADAMs are implicated in tumor cell proliferation, angiogenesis, and metastasis. This review will focus on the contribution of the aforementioned metalloproteinases in regulating gynecological disorders and their subsequent manipulation for therapeutic intervention.
format	article
author	Yasmin Begum Anuradha Pandit Snehasikta Swarnakar
author_facet	Yasmin Begum Anuradha Pandit Snehasikta Swarnakar
author_sort	Yasmin Begum
title	Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases
title_short	Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases
title_full	Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases
title_fullStr	Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases
title_full_unstemmed	Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases
title_sort	insights into the regulation of gynecological inflammation-mediated malignancy by metalloproteinases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e4be654a16f8428ca2673b0d5a0c7959
work_keys_str_mv	AT yasminbegum insightsintotheregulationofgynecologicalinflammationmediatedmalignancybymetalloproteinases AT anuradhapandit insightsintotheregulationofgynecologicalinflammationmediatedmalignancybymetalloproteinases AT snehasiktaswarnakar insightsintotheregulationofgynecologicalinflammationmediatedmalignancybymetalloproteinases
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Insights Into the Regulation of Gynecological Inflammation-Mediated Malignancy by Metalloproteinases

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