PD-L1 expression in angiomatoid fibrous histiocytoma

Abstract Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of intermediate malignancy. Treatment options for unresectable and/or metastatic tumors are very limited. Immunotherapy with PD-1/PD-L1 inhibitors may be worth exploring. The aim of this study was to evaluate the expression of PD-L1 in...

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Autores principales:	Joshua Byers, Hong Yin, Heather Rytting, Suzanna Logan, Mai He, Zhongxin Yu, Dehua Wang, Mikako Warren, Shamlal Mangray, Louis P. Dehner, Shengmei Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4bfade4fa5245b298db32f35f0995ea
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spelling	oai:doaj.org-article:e4bfade4fa5245b298db32f35f0995ea2021-12-02T14:16:26ZPD-L1 expression in angiomatoid fibrous histiocytoma10.1038/s41598-021-81746-y2045-2322https://doaj.org/article/e4bfade4fa5245b298db32f35f0995ea2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81746-yhttps://doaj.org/toc/2045-2322Abstract Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of intermediate malignancy. Treatment options for unresectable and/or metastatic tumors are very limited. Immunotherapy with PD-1/PD-L1 inhibitors may be worth exploring. The aim of this study was to evaluate the expression of PD-L1 in AFHs. PD-L1 expression was assessed on 36 AFHs from 36 pediatric patients by immunohistochemical staining of PD-L1 (clone 22C3). Positivity was defined as membranous expression in ≥ 1% of either tumor or immune cells. The correlations between PD-L1 expression and clinicopathologic features were assessed. Two patients had lymph node metastasis. All patients underwent surgical resection; three of them also had systemic chemotherapy. Three patients had recurrence after initial resection; all patients were alive with a median follow-up of 2.5 years. Overall, twenty-two (61%) tumors were positively stained for PD-L1 and positivity was seen on both tumor and immune cells in eighteen of the 22 tumors. A positive correlation was found between tumor cell PD-L1 expression and CD8+ T-cell infiltration. There were no statistically significant differences between the status of PD-L1 expression and the clinicopathological features assessed. PD-L1 expression was identified in 61% of AFHs with a predominantly adaptive pattern. Our findings provide a rationale for future studies evaluating the potential of checkpoint immunotherapy for patients with unresectable and/or metastatic tumor.Joshua ByersHong YinHeather RyttingSuzanna LoganMai HeZhongxin YuDehua WangMikako WarrenShamlal MangrayLouis P. DehnerShengmei ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joshua Byers Hong Yin Heather Rytting Suzanna Logan Mai He Zhongxin Yu Dehua Wang Mikako Warren Shamlal Mangray Louis P. Dehner Shengmei Zhou PD-L1 expression in angiomatoid fibrous histiocytoma
description	Abstract Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of intermediate malignancy. Treatment options for unresectable and/or metastatic tumors are very limited. Immunotherapy with PD-1/PD-L1 inhibitors may be worth exploring. The aim of this study was to evaluate the expression of PD-L1 in AFHs. PD-L1 expression was assessed on 36 AFHs from 36 pediatric patients by immunohistochemical staining of PD-L1 (clone 22C3). Positivity was defined as membranous expression in ≥ 1% of either tumor or immune cells. The correlations between PD-L1 expression and clinicopathologic features were assessed. Two patients had lymph node metastasis. All patients underwent surgical resection; three of them also had systemic chemotherapy. Three patients had recurrence after initial resection; all patients were alive with a median follow-up of 2.5 years. Overall, twenty-two (61%) tumors were positively stained for PD-L1 and positivity was seen on both tumor and immune cells in eighteen of the 22 tumors. A positive correlation was found between tumor cell PD-L1 expression and CD8+ T-cell infiltration. There were no statistically significant differences between the status of PD-L1 expression and the clinicopathological features assessed. PD-L1 expression was identified in 61% of AFHs with a predominantly adaptive pattern. Our findings provide a rationale for future studies evaluating the potential of checkpoint immunotherapy for patients with unresectable and/or metastatic tumor.
format	article
author	Joshua Byers Hong Yin Heather Rytting Suzanna Logan Mai He Zhongxin Yu Dehua Wang Mikako Warren Shamlal Mangray Louis P. Dehner Shengmei Zhou
author_facet	Joshua Byers Hong Yin Heather Rytting Suzanna Logan Mai He Zhongxin Yu Dehua Wang Mikako Warren Shamlal Mangray Louis P. Dehner Shengmei Zhou
author_sort	Joshua Byers
title	PD-L1 expression in angiomatoid fibrous histiocytoma
title_short	PD-L1 expression in angiomatoid fibrous histiocytoma
title_full	PD-L1 expression in angiomatoid fibrous histiocytoma
title_fullStr	PD-L1 expression in angiomatoid fibrous histiocytoma
title_full_unstemmed	PD-L1 expression in angiomatoid fibrous histiocytoma
title_sort	pd-l1 expression in angiomatoid fibrous histiocytoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e4bfade4fa5245b298db32f35f0995ea
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PD-L1 expression in angiomatoid fibrous histiocytoma

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