The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.

The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the few cancers in which a continuous increase in incidence has been observed over several years. Drug resistance is a major problem in the treatment of HCC. In the present study, we used salinomycin (Sal) and 5-fluorouracil (5-FU) combination therapy on HCC...

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Autores principales: Fan Wang, Weiqi Dai, Yugang Wang, Miao Shen, Kan Chen, Ping Cheng, Yan Zhang, Chengfen Wang, Jingjing Li, Yuanyuan Zheng, Jie Lu, Jing Yang, Rong Zhu, Huawei Zhang, Yingqun Zhou, Ling Xu, Chuanyong Guo
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Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/e4c1485a1a6f45a2b249f2fa91b003d9
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spelling oai:doaj.org-article:e4c1485a1a6f45a2b249f2fa91b003d92021-11-18T08:20:00ZThe synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.1932-620310.1371/journal.pone.0097414https://doaj.org/article/e4c1485a1a6f45a2b249f2fa91b003d92014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24816638/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Hepatocellular carcinoma (HCC) is one of the few cancers in which a continuous increase in incidence has been observed over several years. Drug resistance is a major problem in the treatment of HCC. In the present study, we used salinomycin (Sal) and 5-fluorouracil (5-FU) combination therapy on HCC cell lines Huh7, LM3 and SMMC-7721 and nude mice subcutaneously tumor model to study whether Sal could increase the sensitivity of hepatoma cells to the traditional chemotherapeutic agent such as 5-FU. The combination of Sal and 5-FU resulted in a synergistic antitumor effect against liver tumors both in vitro and in vivo. Sal reversed the 5-FU-induced increase in CD133(+) EPCAM(+) cells, epithelial-mesenchymal transition and activation of the Wnt/β-catenin signaling pathway. The combination of Sal and 5-FU may provide us with a new approach to reverse drug resistant for the treatment of patients with HCC.Fan WangWeiqi DaiYugang WangMiao ShenKan ChenPing ChengYan ZhangChengfen WangJingjing LiYuanyuan ZhengJie LuJing YangRong ZhuHuawei ZhangYingqun ZhouLing XuChuanyong GuoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97414 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Fan Wang
Weiqi Dai
Yugang Wang
Miao Shen
Kan Chen
Ping Cheng
Yan Zhang
Chengfen Wang
Jingjing Li
Yuanyuan Zheng
Jie Lu
Jing Yang
Rong Zhu
Huawei Zhang
Yingqun Zhou
Ling Xu
Chuanyong Guo
The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.
description Hepatocellular carcinoma (HCC) is one of the few cancers in which a continuous increase in incidence has been observed over several years. Drug resistance is a major problem in the treatment of HCC. In the present study, we used salinomycin (Sal) and 5-fluorouracil (5-FU) combination therapy on HCC cell lines Huh7, LM3 and SMMC-7721 and nude mice subcutaneously tumor model to study whether Sal could increase the sensitivity of hepatoma cells to the traditional chemotherapeutic agent such as 5-FU. The combination of Sal and 5-FU resulted in a synergistic antitumor effect against liver tumors both in vitro and in vivo. Sal reversed the 5-FU-induced increase in CD133(+) EPCAM(+) cells, epithelial-mesenchymal transition and activation of the Wnt/β-catenin signaling pathway. The combination of Sal and 5-FU may provide us with a new approach to reverse drug resistant for the treatment of patients with HCC.
format article
author Fan Wang
Weiqi Dai
Yugang Wang
Miao Shen
Kan Chen
Ping Cheng
Yan Zhang
Chengfen Wang
Jingjing Li
Yuanyuan Zheng
Jie Lu
Jing Yang
Rong Zhu
Huawei Zhang
Yingqun Zhou
Ling Xu
Chuanyong Guo
author_facet Fan Wang
Weiqi Dai
Yugang Wang
Miao Shen
Kan Chen
Ping Cheng
Yan Zhang
Chengfen Wang
Jingjing Li
Yuanyuan Zheng
Jie Lu
Jing Yang
Rong Zhu
Huawei Zhang
Yingqun Zhou
Ling Xu
Chuanyong Guo
author_sort Fan Wang
title The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.
title_short The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.
title_full The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.
title_fullStr The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.
title_full_unstemmed The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.
title_sort synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/e4c1485a1a6f45a2b249f2fa91b003d9
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