Dual function of HPF1 in the modulation of PARP1 and PARP2 activities

Kurgina et al. conduct in vitro characterization of the effect of HPF1 on the catalytic output of PARP1 and PARP2 under several experimental conditions. The authors report that the DNAdependent and DNA-independent autoPARylation of PARP1 and PARP2, as well as the heteroPARylation of histones in comp...

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Autores principales:	Tatyana A. Kurgina, Nina A. Moor, Mikhail M. Kutuzov, Konstantin N. Naumenko, Alexander A. Ukraintsev, Olga I. Lavrik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e4c35787c23446cd93c6e3d3eff5af73
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spelling	oai:doaj.org-article:e4c35787c23446cd93c6e3d3eff5af732021-11-07T12:20:18ZDual function of HPF1 in the modulation of PARP1 and PARP2 activities10.1038/s42003-021-02780-02399-3642https://doaj.org/article/e4c35787c23446cd93c6e3d3eff5af732021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02780-0https://doaj.org/toc/2399-3642Kurgina et al. conduct in vitro characterization of the effect of HPF1 on the catalytic output of PARP1 and PARP2 under several experimental conditions. The authors report that the DNAdependent and DNA-independent autoPARylation of PARP1 and PARP2, as well as the heteroPARylation of histones in complex with the nucleosome are stimulated by HPF1 in a certain range of HPF1 and NAD + concentrations.Tatyana A. KurginaNina A. MoorMikhail M. KutuzovKonstantin N. NaumenkoAlexander A. UkraintsevOlga I. LavrikNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tatyana A. Kurgina Nina A. Moor Mikhail M. Kutuzov Konstantin N. Naumenko Alexander A. Ukraintsev Olga I. Lavrik Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
description	Kurgina et al. conduct in vitro characterization of the effect of HPF1 on the catalytic output of PARP1 and PARP2 under several experimental conditions. The authors report that the DNAdependent and DNA-independent autoPARylation of PARP1 and PARP2, as well as the heteroPARylation of histones in complex with the nucleosome are stimulated by HPF1 in a certain range of HPF1 and NAD + concentrations.
format	article
author	Tatyana A. Kurgina Nina A. Moor Mikhail M. Kutuzov Konstantin N. Naumenko Alexander A. Ukraintsev Olga I. Lavrik
author_facet	Tatyana A. Kurgina Nina A. Moor Mikhail M. Kutuzov Konstantin N. Naumenko Alexander A. Ukraintsev Olga I. Lavrik
author_sort	Tatyana A. Kurgina
title	Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
title_short	Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
title_full	Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
title_fullStr	Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
title_full_unstemmed	Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
title_sort	dual function of hpf1 in the modulation of parp1 and parp2 activities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e4c35787c23446cd93c6e3d3eff5af73
work_keys_str_mv	AT tatyanaakurgina dualfunctionofhpf1inthemodulationofparp1andparp2activities AT ninaamoor dualfunctionofhpf1inthemodulationofparp1andparp2activities AT mikhailmkutuzov dualfunctionofhpf1inthemodulationofparp1andparp2activities AT konstantinnnaumenko dualfunctionofhpf1inthemodulationofparp1andparp2activities AT alexanderaukraintsev dualfunctionofhpf1inthemodulationofparp1andparp2activities AT olgailavrik dualfunctionofhpf1inthemodulationofparp1andparp2activities
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Dual function of HPF1 in the modulation of PARP1 and PARP2 activities

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