Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance

Individual bacteria within isogenic populations can differ in antibiotic tolerance. Here, Libby et al. show that antibiotic tolerance variability can be driven by ‘noisy’ expression of a gene encoding a (p)ppGpp synthetase, which is in turn regulated by multisite phosphorylation of a transcription f...

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Main Authors:	Elizabeth A. Libby, Shlomi Reuveni, Jonathan Dworkin
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/e4c40bdcefad4de1998d61d8eb4766d4
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id	oai:doaj.org-article:e4c40bdcefad4de1998d61d8eb4766d4
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spelling	oai:doaj.org-article:e4c40bdcefad4de1998d61d8eb4766d42021-12-02T15:35:54ZMultisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance10.1038/s41467-019-13127-z2041-1723https://doaj.org/article/e4c40bdcefad4de1998d61d8eb4766d42019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13127-zhttps://doaj.org/toc/2041-1723Individual bacteria within isogenic populations can differ in antibiotic tolerance. Here, Libby et al. show that antibiotic tolerance variability can be driven by ‘noisy’ expression of a gene encoding a (p)ppGpp synthetase, which is in turn regulated by multisite phosphorylation of a transcription factor.Elizabeth A. LibbyShlomi ReuveniJonathan DworkinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth A. Libby Shlomi Reuveni Jonathan Dworkin Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance
description	Individual bacteria within isogenic populations can differ in antibiotic tolerance. Here, Libby et al. show that antibiotic tolerance variability can be driven by ‘noisy’ expression of a gene encoding a (p)ppGpp synthetase, which is in turn regulated by multisite phosphorylation of a transcription factor.
format	article
author	Elizabeth A. Libby Shlomi Reuveni Jonathan Dworkin
author_facet	Elizabeth A. Libby Shlomi Reuveni Jonathan Dworkin
author_sort	Elizabeth A. Libby
title	Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance
title_short	Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance
title_full	Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance
title_fullStr	Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance
title_full_unstemmed	Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance
title_sort	multisite phosphorylation drives phenotypic variation in (p)ppgpp synthetase-dependent antibiotic tolerance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4c40bdcefad4de1998d61d8eb4766d4
work_keys_str_mv	AT elizabethalibby multisitephosphorylationdrivesphenotypicvariationinpppgppsynthetasedependentantibiotictolerance AT shlomireuveni multisitephosphorylationdrivesphenotypicvariationinpppgppsynthetasedependentantibiotictolerance AT jonathandworkin multisitephosphorylationdrivesphenotypicvariationinpppgppsynthetasedependentantibiotictolerance
_version_	1718386446897774592

Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance

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