PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain oxidative stress sensitivity and epigenetic changes.

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Autores principales:	Christopher R. S. Banerji, Maryna Panamarova, Husam Hebaishi, Robert B. White, Frédéric Relaix, Simone Severini, Peter S. Zammit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4c41a2342de44989834fb0cef7eaaf9
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spelling	oai:doaj.org-article:e4c41a2342de44989834fb0cef7eaaf92021-12-02T15:38:50ZPAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle10.1038/s41467-017-01200-42041-1723https://doaj.org/article/e4c41a2342de44989834fb0cef7eaaf92017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01200-4https://doaj.org/toc/2041-1723Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain oxidative stress sensitivity and epigenetic changes.Christopher R. S. BanerjiMaryna PanamarovaHusam HebaishiRobert B. WhiteFrédéric RelaixSimone SeveriniPeter S. ZammitNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher R. S. Banerji Maryna Panamarova Husam Hebaishi Robert B. White Frédéric Relaix Simone Severini Peter S. Zammit PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle
description	Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain oxidative stress sensitivity and epigenetic changes.
format	article
author	Christopher R. S. Banerji Maryna Panamarova Husam Hebaishi Robert B. White Frédéric Relaix Simone Severini Peter S. Zammit
author_facet	Christopher R. S. Banerji Maryna Panamarova Husam Hebaishi Robert B. White Frédéric Relaix Simone Severini Peter S. Zammit
author_sort	Christopher R. S. Banerji
title	PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle
title_short	PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle
title_full	PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle
title_fullStr	PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle
title_full_unstemmed	PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle
title_sort	pax7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e4c41a2342de44989834fb0cef7eaaf9
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_version_	1718386080988790784

PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

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