Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience

Background: Axillary lymph node metastasis (ALNM) is one of the important prognostic factors of breast cancer. The objective of this study was to assess the risk of ALNM in different molecular subtypes determined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fact...

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Autores principales:	Dharmendra Singh, Soumen Mukherjee
Formato:	article
Lenguaje:	EN
Publicado:	Kaviani Breast Disease Institute 2021
Materias:	molecular subtypes Breast cancer Axillary lymph node Metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e4c7076e1a014884b98a18cdc8dc23fc
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spelling	oai:doaj.org-article:e4c7076e1a014884b98a18cdc8dc23fc2021-12-04T02:18:54ZImpact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience10.32768/abc.202184305-3122383-0433https://doaj.org/article/e4c7076e1a014884b98a18cdc8dc23fc2021-10-01T00:00:00Zhttps://www.archbreastcancer.com/index.php/abc/article/view/428https://doaj.org/toc/2383-0433 Background: Axillary lymph node metastasis (ALNM) is one of the important prognostic factors of breast cancer. The objective of this study was to assess the risk of ALNM in different molecular subtypes determined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (her2neu) of breast cancer. Methods: This retrospective study was conducted on patients who had undergone upfront breast conserving surgery (BCS) or modified radical mastectomy (MRM). Patients were classified as HR (hormone receptor) +/ her2neu- (ER or PR positive and her2neu negative), HR+/her2neu+ (ER or PR positive and her2neu positive), HR-/her2neu- (ER, PR and her2neu negative or triple negative or basal type), and HR-/her2neu+ (ER or PR negative and her2neu positive). The association between clinicopathological variables and ALNM was evaluated in logistic regression analyses. Results: In this study, 476 patients met the inclusion criteria, and had 67.2% ALNM at diagnosis. ALNM was statistically significantly correlated with age ≤ 40 years (p=0.026), tumor grade (p=0.007), pathological tumor size (P<0.001), estrogen receptor (P=0.045), molecular subtypes (P=0.021), LVI (P<0.001), and PNI (P<0.001). Post Hoc test revealed that HR-/her2neu+ subtypes of breast cancer had the highest and HR+/her2neu- had the lowest risk of ALNM. Conclusion: ALNM may be predicted by molecular subtypes of breast cancer. The risk of ALNM is less in TNBC although it is clinically more aggressive. These findings may play an important role in gauging the individualized axillary management in breast cancer. Dharmendra SinghSoumen MukherjeeKaviani Breast Disease Institutearticlemolecular subtypesBreast cancerAxillary lymph node MetastasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENArchives of Breast Cancer (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	molecular subtypes Breast cancer Axillary lymph node Metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	molecular subtypes Breast cancer Axillary lymph node Metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Dharmendra Singh Soumen Mukherjee Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience
description	Background: Axillary lymph node metastasis (ALNM) is one of the important prognostic factors of breast cancer. The objective of this study was to assess the risk of ALNM in different molecular subtypes determined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (her2neu) of breast cancer. Methods: This retrospective study was conducted on patients who had undergone upfront breast conserving surgery (BCS) or modified radical mastectomy (MRM). Patients were classified as HR (hormone receptor) +/ her2neu- (ER or PR positive and her2neu negative), HR+/her2neu+ (ER or PR positive and her2neu positive), HR-/her2neu- (ER, PR and her2neu negative or triple negative or basal type), and HR-/her2neu+ (ER or PR negative and her2neu positive). The association between clinicopathological variables and ALNM was evaluated in logistic regression analyses. Results: In this study, 476 patients met the inclusion criteria, and had 67.2% ALNM at diagnosis. ALNM was statistically significantly correlated with age ≤ 40 years (p=0.026), tumor grade (p=0.007), pathological tumor size (P<0.001), estrogen receptor (P=0.045), molecular subtypes (P=0.021), LVI (P<0.001), and PNI (P<0.001). Post Hoc test revealed that HR-/her2neu+ subtypes of breast cancer had the highest and HR+/her2neu- had the lowest risk of ALNM. Conclusion: ALNM may be predicted by molecular subtypes of breast cancer. The risk of ALNM is less in TNBC although it is clinically more aggressive. These findings may play an important role in gauging the individualized axillary management in breast cancer.
format	article
author	Dharmendra Singh Soumen Mukherjee
author_facet	Dharmendra Singh Soumen Mukherjee
author_sort	Dharmendra Singh
title	Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience
title_short	Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience
title_full	Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience
title_fullStr	Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience
title_full_unstemmed	Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience
title_sort	impact of molecular subtypes of breast cancer on axillary lymph node metastasis: a tertiary center experience
publisher	Kaviani Breast Disease Institute
publishDate	2021
url	https://doaj.org/article/e4c7076e1a014884b98a18cdc8dc23fc
work_keys_str_mv	AT dharmendrasingh impactofmolecularsubtypesofbreastcanceronaxillarylymphnodemetastasisatertiarycenterexperience AT soumenmukherjee impactofmolecularsubtypesofbreastcanceronaxillarylymphnodemetastasisatertiarycenterexperience
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Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience

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