Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer
Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through a distal enhancer, and these dormant cells are ad...
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Nature Portfolio
2021
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oai:doaj.org-article:e4c712e9c2534821b3dbea828efb94702021-12-02T18:36:59ZGlucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer10.1038/s41467-021-24537-32041-1723https://doaj.org/article/e4c712e9c2534821b3dbea828efb94702021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24537-3https://doaj.org/toc/2041-1723Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through a distal enhancer, and these dormant cells are addicted to IGF-1R signalling pathway.Stefan PrekovicKarianne SchuurmanIsabel Mayayo-PeraltaAnna G. ManjónMark BuijsSelçuk YavuzMax D. WellensteinAlejandro BarreraKim MonkhorstAnne HuberBen MorrisCor LieftinkTheofilos ChalkiadakisFerhat AlkanJoana SilvaBalázs GyőrffyLiesbeth HoekmanBram van den BroekHans TeunissenDonna O. DebetsTesa SeversonJos JonkersTimothy ReddyKarin E. de VisserWilliam FallerRoderick BeijersbergenMaarten AltelaarElzo de WitRene MedemaWilbert ZwartNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Stefan Prekovic Karianne Schuurman Isabel Mayayo-Peralta Anna G. Manjón Mark Buijs Selçuk Yavuz Max D. Wellenstein Alejandro Barrera Kim Monkhorst Anne Huber Ben Morris Cor Lieftink Theofilos Chalkiadakis Ferhat Alkan Joana Silva Balázs Győrffy Liesbeth Hoekman Bram van den Broek Hans Teunissen Donna O. Debets Tesa Severson Jos Jonkers Timothy Reddy Karin E. de Visser William Faller Roderick Beijersbergen Maarten Altelaar Elzo de Wit Rene Medema Wilbert Zwart Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer |
| description |
Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through a distal enhancer, and these dormant cells are addicted to IGF-1R signalling pathway. |
| format |
article |
| author |
Stefan Prekovic Karianne Schuurman Isabel Mayayo-Peralta Anna G. Manjón Mark Buijs Selçuk Yavuz Max D. Wellenstein Alejandro Barrera Kim Monkhorst Anne Huber Ben Morris Cor Lieftink Theofilos Chalkiadakis Ferhat Alkan Joana Silva Balázs Győrffy Liesbeth Hoekman Bram van den Broek Hans Teunissen Donna O. Debets Tesa Severson Jos Jonkers Timothy Reddy Karin E. de Visser William Faller Roderick Beijersbergen Maarten Altelaar Elzo de Wit Rene Medema Wilbert Zwart |
| author_facet |
Stefan Prekovic Karianne Schuurman Isabel Mayayo-Peralta Anna G. Manjón Mark Buijs Selçuk Yavuz Max D. Wellenstein Alejandro Barrera Kim Monkhorst Anne Huber Ben Morris Cor Lieftink Theofilos Chalkiadakis Ferhat Alkan Joana Silva Balázs Győrffy Liesbeth Hoekman Bram van den Broek Hans Teunissen Donna O. Debets Tesa Severson Jos Jonkers Timothy Reddy Karin E. de Visser William Faller Roderick Beijersbergen Maarten Altelaar Elzo de Wit Rene Medema Wilbert Zwart |
| author_sort |
Stefan Prekovic |
| title |
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer |
| title_short |
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer |
| title_full |
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer |
| title_fullStr |
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer |
| title_full_unstemmed |
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer |
| title_sort |
glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e4c712e9c2534821b3dbea828efb9470 |
| work_keys_str_mv |
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