A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol

Abstract Background Critically ill patients with COVID-19 are at an increased risk of developing secondary bacterial infections. These are both difficult to diagnose and are associated with an increased mortality. Metabolomics may aid clinicians in diagnosing secondary bacterial infections in COVID-...

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Autores principales:	Gordan McCreath, Phillip D. Whitfield, Andrew J. Roe, Malcolm J. Watson, Malcolm A. B. Sim
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Metabolomics Secondary infection COVID-19 Critical care Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/e4c72e8e3a664370affdcbce8a6575df
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spelling	oai:doaj.org-article:e4c72e8e3a664370affdcbce8a6575df2021-12-05T12:26:14ZA Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol10.1186/s12879-021-06832-y1471-2334https://doaj.org/article/e4c72e8e3a664370affdcbce8a6575df2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06832-yhttps://doaj.org/toc/1471-2334Abstract Background Critically ill patients with COVID-19 are at an increased risk of developing secondary bacterial infections. These are both difficult to diagnose and are associated with an increased mortality. Metabolomics may aid clinicians in diagnosing secondary bacterial infections in COVID-19 through identification and quantification of disease specific biomarkers, with the aim of identifying underlying causative microorganisms and directing antimicrobial therapy. Methods This is a multi-centre prospective diagnostic observational study. Patients with COVID-19 will be recruited from critical care units in three Scottish hospitals. Three serial blood samples will be taken from patients, and an additional sample taken if a patient shows clinical or microbiological evidence of secondary infection. Samples will be analysed using LC–MS and subjected to bioinformatic processing and statistical analysis to explore the metabolite changes associated with bacterial infections in COVID-19 patients. Comparisons of the data sets will be made with standard microbiological and biochemical methods of diagnosing infection. Discussion Metabolomics analyses may provide additional strategies for identifying secondary infections, which might permit faster initiation of specific tailored antimicrobial therapy to critically ill patients with COVID-19.Gordan McCreathPhillip D. WhitfieldAndrew J. RoeMalcolm J. WatsonMalcolm A. B. SimBMCarticleMetabolomicsSecondary infectionCOVID-19Critical careInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metabolomics Secondary infection COVID-19 Critical care Infectious and parasitic diseases RC109-216
spellingShingle	Metabolomics Secondary infection COVID-19 Critical care Infectious and parasitic diseases RC109-216 Gordan McCreath Phillip D. Whitfield Andrew J. Roe Malcolm J. Watson Malcolm A. B. Sim A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol
description	Abstract Background Critically ill patients with COVID-19 are at an increased risk of developing secondary bacterial infections. These are both difficult to diagnose and are associated with an increased mortality. Metabolomics may aid clinicians in diagnosing secondary bacterial infections in COVID-19 through identification and quantification of disease specific biomarkers, with the aim of identifying underlying causative microorganisms and directing antimicrobial therapy. Methods This is a multi-centre prospective diagnostic observational study. Patients with COVID-19 will be recruited from critical care units in three Scottish hospitals. Three serial blood samples will be taken from patients, and an additional sample taken if a patient shows clinical or microbiological evidence of secondary infection. Samples will be analysed using LC–MS and subjected to bioinformatic processing and statistical analysis to explore the metabolite changes associated with bacterial infections in COVID-19 patients. Comparisons of the data sets will be made with standard microbiological and biochemical methods of diagnosing infection. Discussion Metabolomics analyses may provide additional strategies for identifying secondary infections, which might permit faster initiation of specific tailored antimicrobial therapy to critically ill patients with COVID-19.
format	article
author	Gordan McCreath Phillip D. Whitfield Andrew J. Roe Malcolm J. Watson Malcolm A. B. Sim
author_facet	Gordan McCreath Phillip D. Whitfield Andrew J. Roe Malcolm J. Watson Malcolm A. B. Sim
author_sort	Gordan McCreath
title	A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol
title_short	A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol
title_full	A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol
title_fullStr	A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol
title_full_unstemmed	A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol
title_sort	metabolomics approach for the diagnosis of secondary infections in covid-19 (mosaic): a study protocol
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e4c72e8e3a664370affdcbce8a6575df
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A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol

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