Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

Defects in neural crest development cause neurocristopathies and cancer, but what regulates this is unclear. Here, the authors show that glycogen synthase kinase 3 (GSK3) regulates migration of neural crest cells, as shown on genetic deletion of GSK3 in the mouse, and that this acts via anaplastic l...

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Autores principales:	Sandra G. Gonzalez Malagon, Anna M. Lopez Muñoz, Daniel Doro, Triòna G. Bolger, Evon Poon, Elizabeth R. Tucker, Hadeel Adel Al-Lami, Matthias Krause, Christopher J. Phiel, Louis Chesler, Karen J. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4c7c11b83d34ab0a2deda0f04ee42da
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spelling	oai:doaj.org-article:e4c7c11b83d34ab0a2deda0f04ee42da2021-12-02T16:49:51ZGlycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus10.1038/s41467-018-03512-52041-1723https://doaj.org/article/e4c7c11b83d34ab0a2deda0f04ee42da2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03512-5https://doaj.org/toc/2041-1723Defects in neural crest development cause neurocristopathies and cancer, but what regulates this is unclear. Here, the authors show that glycogen synthase kinase 3 (GSK3) regulates migration of neural crest cells, as shown on genetic deletion of GSK3 in the mouse, and that this acts via anaplastic lymphoma kinase.Sandra G. Gonzalez MalagonAnna M. Lopez MuñozDaniel DoroTriòna G. BolgerEvon PoonElizabeth R. TuckerHadeel Adel Al-LamiMatthias KrauseChristopher J. PhielLouis CheslerKaren J. LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandra G. Gonzalez Malagon Anna M. Lopez Muñoz Daniel Doro Triòna G. Bolger Evon Poon Elizabeth R. Tucker Hadeel Adel Al-Lami Matthias Krause Christopher J. Phiel Louis Chesler Karen J. Liu Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
description	Defects in neural crest development cause neurocristopathies and cancer, but what regulates this is unclear. Here, the authors show that glycogen synthase kinase 3 (GSK3) regulates migration of neural crest cells, as shown on genetic deletion of GSK3 in the mouse, and that this acts via anaplastic lymphoma kinase.
format	article
author	Sandra G. Gonzalez Malagon Anna M. Lopez Muñoz Daniel Doro Triòna G. Bolger Evon Poon Elizabeth R. Tucker Hadeel Adel Al-Lami Matthias Krause Christopher J. Phiel Louis Chesler Karen J. Liu
author_facet	Sandra G. Gonzalez Malagon Anna M. Lopez Muñoz Daniel Doro Triòna G. Bolger Evon Poon Elizabeth R. Tucker Hadeel Adel Al-Lami Matthias Krause Christopher J. Phiel Louis Chesler Karen J. Liu
author_sort	Sandra G. Gonzalez Malagon
title	Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
title_short	Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
title_full	Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
title_fullStr	Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
title_full_unstemmed	Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
title_sort	glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and xenopus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e4c7c11b83d34ab0a2deda0f04ee42da
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Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

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