Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads

Repetitive sequences in complex eukaryote genomes can cause fragmented assemblies with incomplete gene sequences and unanchored or mispositioned contigs. Here, the authors report HERA, a method to improve genome assemblies by efficiently resolving repeats using single-molecule sequencing data.

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Detalles Bibliográficos
Autores principales:	Huilong Du, Chengzhi Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4cb5234c1a7488d86300fa3e1c6f161
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spelling	oai:doaj.org-article:e4cb5234c1a7488d86300fa3e1c6f1612021-12-02T17:02:02ZAssembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads10.1038/s41467-019-13355-32041-1723https://doaj.org/article/e4cb5234c1a7488d86300fa3e1c6f1612019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13355-3https://doaj.org/toc/2041-1723Repetitive sequences in complex eukaryote genomes can cause fragmented assemblies with incomplete gene sequences and unanchored or mispositioned contigs. Here, the authors report HERA, a method to improve genome assemblies by efficiently resolving repeats using single-molecule sequencing data.Huilong DuChengzhi LiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huilong Du Chengzhi Liang Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads
description	Repetitive sequences in complex eukaryote genomes can cause fragmented assemblies with incomplete gene sequences and unanchored or mispositioned contigs. Here, the authors report HERA, a method to improve genome assemblies by efficiently resolving repeats using single-molecule sequencing data.
format	article
author	Huilong Du Chengzhi Liang
author_facet	Huilong Du Chengzhi Liang
author_sort	Huilong Du
title	Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads
title_short	Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads
title_full	Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads
title_fullStr	Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads
title_full_unstemmed	Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads
title_sort	assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4cb5234c1a7488d86300fa3e1c6f161
work_keys_str_mv	AT huilongdu assemblyofchromosomescalecontigsbyefficientlyresolvingrepetitivesequenceswithlongreads AT chengzhiliang assemblyofchromosomescalecontigsbyefficientlyresolvingrepetitivesequenceswithlongreads
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Assembly of chromosome-scale contigs by efficiently resolving repetitive sequences with long reads

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