The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome

ABSTRACT Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly...

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Autores principales:	Anthony M. Cadena, JoAnne L. Flynn, Sarah M. Fortune
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e4d1058607c84486bcd304fd20fbf37e
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spelling	oai:doaj.org-article:e4d1058607c84486bcd304fd20fbf37e2021-11-15T15:41:42ZThe Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome10.1128/mBio.00342-162150-7511https://doaj.org/article/e4d1058607c84486bcd304fd20fbf37e2016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00342-16https://doaj.org/toc/2150-7511ABSTRACT Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly, it has become clear that early events in infection are of major importance in the eventual outcome of the infection. Studying such events in humans is challenging, as they occur within the lung and thoracic lymph nodes, and any clinical signs of early infection are relatively nonspecific. Nonetheless, clinical studies and animal models of tuberculosis have provided new insights into the local events that occur in the first few weeks of tuberculosis. Development of an effective vaccine requires a clear understanding of the successful (and detrimental) early host responses against M. tuberculosis, with the goal to improve upon natural immune responses and prevent infection or disease.Anthony M. CadenaJoAnne L. FlynnSarah M. FortuneAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Anthony M. Cadena JoAnne L. Flynn Sarah M. Fortune The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome
description	ABSTRACT Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly, it has become clear that early events in infection are of major importance in the eventual outcome of the infection. Studying such events in humans is challenging, as they occur within the lung and thoracic lymph nodes, and any clinical signs of early infection are relatively nonspecific. Nonetheless, clinical studies and animal models of tuberculosis have provided new insights into the local events that occur in the first few weeks of tuberculosis. Development of an effective vaccine requires a clear understanding of the successful (and detrimental) early host responses against M. tuberculosis, with the goal to improve upon natural immune responses and prevent infection or disease.
format	article
author	Anthony M. Cadena JoAnne L. Flynn Sarah M. Fortune
author_facet	Anthony M. Cadena JoAnne L. Flynn Sarah M. Fortune
author_sort	Anthony M. Cadena
title	The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome
title_short	The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome
title_full	The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome
title_fullStr	The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome
title_full_unstemmed	The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome
title_sort	importance of first impressions: early events in <named-content content-type="genus-species">mycobacterium tuberculosis</named-content> infection influence outcome
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/e4d1058607c84486bcd304fd20fbf37e
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The Importance of First Impressions: Early Events in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection Influence Outcome

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