Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes

Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes

Alkene hydrodifluoroalkylation is a fruitful strategy for synthesizing medicinally relevant difluoromethylated molecules. Here, the authors report a Markovnikov hydrodifluoroalkylation of aryl and aliphatic alkenes using inexpensive Mg(ClO4)2·6H2O as catalyst and difluoroenoxysilanes as the nucleoph...

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Autores principales: Xiao-Si Hu, Jun-Xiong He, Su-Zhen Dong, Qiu-Hua Zhao, Jin-Sheng Yu, Jian Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e4d4b12b453c48aab89439a02d903c32
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spelling oai:doaj.org-article:e4d4b12b453c48aab89439a02d903c322021-12-02T16:49:16ZRegioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes10.1038/s41467-020-19387-42041-1723https://doaj.org/article/e4d4b12b453c48aab89439a02d903c322020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19387-4https://doaj.org/toc/2041-1723Alkene hydrodifluoroalkylation is a fruitful strategy for synthesizing medicinally relevant difluoromethylated molecules. Here, the authors report a Markovnikov hydrodifluoroalkylation of aryl and aliphatic alkenes using inexpensive Mg(ClO4)2·6H2O as catalyst and difluoroenoxysilanes as the nucleophiles.Xiao-Si HuJun-Xiong HeSu-Zhen DongQiu-Hua ZhaoJin-Sheng YuJian ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiao-Si Hu
Jun-Xiong He
Su-Zhen Dong
Qiu-Hua Zhao
Jin-Sheng Yu
Jian Zhou
Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes
description Alkene hydrodifluoroalkylation is a fruitful strategy for synthesizing medicinally relevant difluoromethylated molecules. Here, the authors report a Markovnikov hydrodifluoroalkylation of aryl and aliphatic alkenes using inexpensive Mg(ClO4)2·6H2O as catalyst and difluoroenoxysilanes as the nucleophiles.
format article
author Xiao-Si Hu
Jun-Xiong He
Su-Zhen Dong
Qiu-Hua Zhao
Jin-Sheng Yu
Jian Zhou
author_facet Xiao-Si Hu
Jun-Xiong He
Su-Zhen Dong
Qiu-Hua Zhao
Jin-Sheng Yu
Jian Zhou
author_sort Xiao-Si Hu
title Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes
title_short Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes
title_full Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes
title_fullStr Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes
title_full_unstemmed Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes
title_sort regioselective markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/e4d4b12b453c48aab89439a02d903c32
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