Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes

Alkene hydrodifluoroalkylation is a fruitful strategy for synthesizing medicinally relevant difluoromethylated molecules. Here, the authors report a Markovnikov hydrodifluoroalkylation of aryl and aliphatic alkenes using inexpensive Mg(ClO4)2·6H2O as catalyst and difluoroenoxysilanes as the nucleoph...

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Autores principales: Xiao-Si Hu, Jun-Xiong He, Su-Zhen Dong, Qiu-Hua Zhao, Jin-Sheng Yu, Jian Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e4d4b12b453c48aab89439a02d903c32
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