Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

Kapustin et al. investigate the intracellular trafficking of anti-KRAS antisense oligonucleotides. They show that the oligonucleotide AZD4785 is recycled via late endosomes in extracellular vesicles in both cells with poor and good oligo productive uptake, and that inducing lysobisphosphatidic acid...

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Autores principales:	Alexander N. Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W. A. Devine, Nicholas J. Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A. Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e4d7d13e7cd04080b03cedf4614a86e6
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spelling	oai:doaj.org-article:e4d7d13e7cd04080b03cedf4614a86e62021-11-07T12:20:32ZAntisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling10.1038/s42003-021-02772-02399-3642https://doaj.org/article/e4d7d13e7cd04080b03cedf4614a86e62021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02772-0https://doaj.org/toc/2399-3642Kapustin et al. investigate the intracellular trafficking of anti-KRAS antisense oligonucleotides. They show that the oligonucleotide AZD4785 is recycled via late endosomes in extracellular vesicles in both cells with poor and good oligo productive uptake, and that inducing lysobisphosphatidic acid in late endosomes or blocking EV recycling enhance AZD4785 activity in cells with poor productive uptake, potentially offering improved treatment strategies.Alexander N. KapustinPaul DaveyDavid LongmireCarl MatthewsEmily LinnaneNitin RustogiMaria StavrouPaul W. A. DevineNicholas J. BondLyndsey HansonSilvia SonziniAlexey RevenkoA. Robert MacLeodSarah RossElisabetta ChiarparinSanyogitta PuriNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alexander N. Kapustin Paul Davey David Longmire Carl Matthews Emily Linnane Nitin Rustogi Maria Stavrou Paul W. A. Devine Nicholas J. Bond Lyndsey Hanson Silvia Sonzini Alexey Revenko A. Robert MacLeod Sarah Ross Elisabetta Chiarparin Sanyogitta Puri Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling
description	Kapustin et al. investigate the intracellular trafficking of anti-KRAS antisense oligonucleotides. They show that the oligonucleotide AZD4785 is recycled via late endosomes in extracellular vesicles in both cells with poor and good oligo productive uptake, and that inducing lysobisphosphatidic acid in late endosomes or blocking EV recycling enhance AZD4785 activity in cells with poor productive uptake, potentially offering improved treatment strategies.
format	article
author	Alexander N. Kapustin Paul Davey David Longmire Carl Matthews Emily Linnane Nitin Rustogi Maria Stavrou Paul W. A. Devine Nicholas J. Bond Lyndsey Hanson Silvia Sonzini Alexey Revenko A. Robert MacLeod Sarah Ross Elisabetta Chiarparin Sanyogitta Puri
author_facet	Alexander N. Kapustin Paul Davey David Longmire Carl Matthews Emily Linnane Nitin Rustogi Maria Stavrou Paul W. A. Devine Nicholas J. Bond Lyndsey Hanson Silvia Sonzini Alexey Revenko A. Robert MacLeod Sarah Ross Elisabetta Chiarparin Sanyogitta Puri
author_sort	Alexander N. Kapustin
title	Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling
title_short	Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling
title_full	Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling
title_fullStr	Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling
title_full_unstemmed	Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling
title_sort	antisense oligonucleotide activity in tumour cells is influenced by intracellular lbpa distribution and extracellular vesicle recycling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e4d7d13e7cd04080b03cedf4614a86e6
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Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

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