Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.

Obesity is a multifactorial disease caused by the interaction between genotype and environment, and it is considered to be a type of addictive alteration. The A1 allele of the DRD2/ANKK1-TaqIA gene has been associated with addictive disorders, with obesity and with the performance in executive funct...

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Autores principales:	Mar Ariza, Maite Garolera, Maria Angeles Jurado, Isabel Garcia-Garcia, Imma Hernan, Consuelo Sánchez-Garre, Maria Vernet-Vernet, Maria Jose Sender-Palacios, Idoia Marques-Iturria, Roser Pueyo, Barbara Segura, Ana Narberhaus
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4ddb0700aec42499345d488432738a5
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spelling	oai:doaj.org-article:e4ddb0700aec42499345d488432738a52021-11-18T07:11:07ZDopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.1932-620310.1371/journal.pone.0041482https://doaj.org/article/e4ddb0700aec42499345d488432738a52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22848508/?tool=EBIhttps://doaj.org/toc/1932-6203Obesity is a multifactorial disease caused by the interaction between genotype and environment, and it is considered to be a type of addictive alteration. The A1 allele of the DRD2/ANKK1-TaqIA gene has been associated with addictive disorders, with obesity and with the performance in executive functions. The 7 repeat allele of the DRD4 gene has likewise been associated with the performance in executive functions, as well as with addictive behaviors and impulsivity. Participants were included in the obesity group (N = 42) if their body mass index (BMI) was equal to or above 30, and in the lean group (N = 42) if their BMI was below 25. The DRD2/ANKK1-TaqIA and DRD4 VNTR polymorphisms were obtained. All subjects underwent neuropsychological assessment. Eating behavior traits were evaluated. The 'DRD2/ANKK1-TaqIA A1-allele status' had a significant effect on almost all the executive variables, but no significant 'DRD4 7R-allele status' effects were observed for any of the executive variables analyzed. There was a significant 'group' x 'DRD2/ANKK1-TaqIA A1-allele status' interaction effect on LN and 'group' x 'DRD4 7R-allele status' interaction effect on TMT B-A score. Being obese and a carrier of the A1 allele of DRD2/ANKK1-TaqIA or the 7R allele of DRD4 VNTR polymorphisms could confer a weakness as regards the performance of executive functions.Mar ArizaMaite GaroleraMaria Angeles JuradoIsabel Garcia-GarciaImma HernanConsuelo Sánchez-GarreMaria Vernet-VernetMaria Jose Sender-PalaciosIdoia Marques-IturriaRoser PueyoBarbara SeguraAna NarberhausPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41482 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mar Ariza Maite Garolera Maria Angeles Jurado Isabel Garcia-Garcia Imma Hernan Consuelo Sánchez-Garre Maria Vernet-Vernet Maria Jose Sender-Palacios Idoia Marques-Iturria Roser Pueyo Barbara Segura Ana Narberhaus Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.
description	Obesity is a multifactorial disease caused by the interaction between genotype and environment, and it is considered to be a type of addictive alteration. The A1 allele of the DRD2/ANKK1-TaqIA gene has been associated with addictive disorders, with obesity and with the performance in executive functions. The 7 repeat allele of the DRD4 gene has likewise been associated with the performance in executive functions, as well as with addictive behaviors and impulsivity. Participants were included in the obesity group (N = 42) if their body mass index (BMI) was equal to or above 30, and in the lean group (N = 42) if their BMI was below 25. The DRD2/ANKK1-TaqIA and DRD4 VNTR polymorphisms were obtained. All subjects underwent neuropsychological assessment. Eating behavior traits were evaluated. The 'DRD2/ANKK1-TaqIA A1-allele status' had a significant effect on almost all the executive variables, but no significant 'DRD4 7R-allele status' effects were observed for any of the executive variables analyzed. There was a significant 'group' x 'DRD2/ANKK1-TaqIA A1-allele status' interaction effect on LN and 'group' x 'DRD4 7R-allele status' interaction effect on TMT B-A score. Being obese and a carrier of the A1 allele of DRD2/ANKK1-TaqIA or the 7R allele of DRD4 VNTR polymorphisms could confer a weakness as regards the performance of executive functions.
format	article
author	Mar Ariza Maite Garolera Maria Angeles Jurado Isabel Garcia-Garcia Imma Hernan Consuelo Sánchez-Garre Maria Vernet-Vernet Maria Jose Sender-Palacios Idoia Marques-Iturria Roser Pueyo Barbara Segura Ana Narberhaus
author_facet	Mar Ariza Maite Garolera Maria Angeles Jurado Isabel Garcia-Garcia Imma Hernan Consuelo Sánchez-Garre Maria Vernet-Vernet Maria Jose Sender-Palacios Idoia Marques-Iturria Roser Pueyo Barbara Segura Ana Narberhaus
author_sort	Mar Ariza
title	Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.
title_short	Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.
title_full	Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.
title_fullStr	Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.
title_full_unstemmed	Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.
title_sort	dopamine genes (drd2/ankk1-taqa1 and drd4-7r) and executive function: their interaction with obesity.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e4ddb0700aec42499345d488432738a5
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Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.

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