Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.

<h4>Background</h4>Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial in...

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Autores principales:	Carolina Barragán-Martínez, Cesar A Speck-Hernández, Gladis Montoya-Ortiz, Rubén D Mantilla, Juan-Manuel Anaya, Adriana Rojas-Villarraga
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4decee6653e49ae8a56d567e25bba46
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spelling	oai:doaj.org-article:e4decee6653e49ae8a56d567e25bba462021-11-18T08:04:33ZOrganic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0051506https://doaj.org/article/e4decee6653e49ae8a56d567e25bba462012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284705/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs.<h4>Methods and findings</h4>The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value<0.001).<h4>Conclusion</h4>Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.Carolina Barragán-MartínezCesar A Speck-HernándezGladis Montoya-OrtizRubén D MantillaJuan-Manuel AnayaAdriana Rojas-VillarragaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51506 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolina Barragán-Martínez Cesar A Speck-Hernández Gladis Montoya-Ortiz Rubén D Mantilla Juan-Manuel Anaya Adriana Rojas-Villarraga Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
description	<h4>Background</h4>Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs.<h4>Methods and findings</h4>The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value<0.001).<h4>Conclusion</h4>Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.
format	article
author	Carolina Barragán-Martínez Cesar A Speck-Hernández Gladis Montoya-Ortiz Rubén D Mantilla Juan-Manuel Anaya Adriana Rojas-Villarraga
author_facet	Carolina Barragán-Martínez Cesar A Speck-Hernández Gladis Montoya-Ortiz Rubén D Mantilla Juan-Manuel Anaya Adriana Rojas-Villarraga
author_sort	Carolina Barragán-Martínez
title	Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
title_short	Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
title_full	Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
title_fullStr	Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
title_full_unstemmed	Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
title_sort	organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e4decee6653e49ae8a56d567e25bba46
work_keys_str_mv	AT carolinabarraganmartinez organicsolventsasriskfactorforautoimmunediseasesasystematicreviewandmetaanalysis AT cesaraspeckhernandez organicsolventsasriskfactorforautoimmunediseasesasystematicreviewandmetaanalysis AT gladismontoyaortiz organicsolventsasriskfactorforautoimmunediseasesasystematicreviewandmetaanalysis AT rubendmantilla organicsolventsasriskfactorforautoimmunediseasesasystematicreviewandmetaanalysis AT juanmanuelanaya organicsolventsasriskfactorforautoimmunediseasesasystematicreviewandmetaanalysis AT adrianarojasvillarraga organicsolventsasriskfactorforautoimmunediseasesasystematicreviewandmetaanalysis
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Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis.

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