SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

Wounding induces changes in cell identity but the mechanisms regulating this are unclear. Here, the authors show that Sox11/Sox4 expression in the leading edge of wounds converts murine epidermal cells to an embryonic-like state and facilitates repair.

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Autores principales:	Qi Miao, Matthew C. Hill, Fengju Chen, Qianxing Mo, Amy T. Ku, Carlos Ramos, Elisabeth Sock, Véronique Lefebvre, Hoang Nguyen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4e0261339994179b8b179c518cfc69a
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spelling	oai:doaj.org-article:e4e0261339994179b8b179c518cfc69a2021-12-02T16:57:33ZSOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair10.1038/s41467-019-11880-92041-1723https://doaj.org/article/e4e0261339994179b8b179c518cfc69a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11880-9https://doaj.org/toc/2041-1723Wounding induces changes in cell identity but the mechanisms regulating this are unclear. Here, the authors show that Sox11/Sox4 expression in the leading edge of wounds converts murine epidermal cells to an embryonic-like state and facilitates repair.Qi MiaoMatthew C. HillFengju ChenQianxing MoAmy T. KuCarlos RamosElisabeth SockVéronique LefebvreHoang NguyenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Miao Matthew C. Hill Fengju Chen Qianxing Mo Amy T. Ku Carlos Ramos Elisabeth Sock Véronique Lefebvre Hoang Nguyen SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
description	Wounding induces changes in cell identity but the mechanisms regulating this are unclear. Here, the authors show that Sox11/Sox4 expression in the leading edge of wounds converts murine epidermal cells to an embryonic-like state and facilitates repair.
format	article
author	Qi Miao Matthew C. Hill Fengju Chen Qianxing Mo Amy T. Ku Carlos Ramos Elisabeth Sock Véronique Lefebvre Hoang Nguyen
author_facet	Qi Miao Matthew C. Hill Fengju Chen Qianxing Mo Amy T. Ku Carlos Ramos Elisabeth Sock Véronique Lefebvre Hoang Nguyen
author_sort	Qi Miao
title	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
title_short	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
title_full	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
title_fullStr	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
title_full_unstemmed	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
title_sort	sox11 and sox4 drive the reactivation of an embryonic gene program during murine wound repair
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4e0261339994179b8b179c518cfc69a
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SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

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