SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

Wounding induces changes in cell identity but the mechanisms regulating this are unclear. Here, the authors show that Sox11/Sox4 expression in the leading edge of wounds converts murine epidermal cells to an embryonic-like state and facilitates repair.

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Detalles Bibliográficos
Autores principales: Qi Miao, Matthew C. Hill, Fengju Chen, Qianxing Mo, Amy T. Ku, Carlos Ramos, Elisabeth Sock, Véronique Lefebvre, Hoang Nguyen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e4e0261339994179b8b179c518cfc69a
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