Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang

Jun Li,1,&ast; YanXia Ren,1,&ast; SiYuan Li,2 JiaJia Li3 1Endocrinology and Metabolism Department, First Affiliated Hosptital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Shihezi University School of Medicine, Shihezi, Xinji...

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Autores principales:	Li J, Ren Y, Li S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	sost gene polymorphism gene mutation type 2 diabetes mellitus osteoporosis bone mineral density sost protein Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e4e1fe88b8ad4713816b644607662a6c
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spelling	oai:doaj.org-article:e4e1fe88b8ad4713816b644607662a6c2021-12-02T17:55:08ZRelationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang1178-7007https://doaj.org/article/e4e1fe88b8ad4713816b644607662a6c2021-11-01T00:00:00Zhttps://www.dovepress.com/relationship-between-sclerostin-sost-expression-and-genetic-loci-rs851-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Jun Li,1,&ast; YanXia Ren,1,&ast; SiYuan Li,2 JiaJia Li3 1Endocrinology and Metabolism Department, First Affiliated Hosptital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Shihezi University School of Medicine, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 3Endocrinology and Metabolism Department, Second People’s Hospital of Nanyang, Nanyang, Henan Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Li Email xjlijun@163.comBackground: The Wnt signaling pathway plays a valuable role in bone metabolism. SOST is a major inhibitor of the Wnt signaling pathway. The expression of SOST and genetic polymorphism might be associated with bone mineral density in postmenopausal women with type 2 diabetes mellitus (T2DM).Objective: This study aims to explore whether SOST protein expression and genetic locus rs851056, rs1230399 polymorphism is associated with bone mineral density in postmenopausal women with T2DM in Xinjiang.Methods: A total of 136 Xinjiang postmenopausal women were divided into four groups: A (-/-), B (±), C (-/+), and D (+/+) by assessing their OGTT and bone mass. Genetic polymorphisms were determined using the mass ARRAY mass spectrometer.Results: 1) Genotypes and allele frequencies at rs851056 were statistically significant differences in groups B and D patients compared to group A, respectively. 2) Individuals carrying the GG genotype had lower HDL, Ca, and ALP as compared to those carrying the GC/CC genotypes in group C. In contrast, individuals carrying the GG genotype had higher BMD (L1-4) as compared to those carrying the GC/CC genotypes in group D. 3) SOST protein expression levels were higher in groups C and D than in group A. 4). BMD (L1-4) was negatively correlated with SOST protein. 5) Multiple linear regression analysis for BMD-dependent variables showed that the decrease of BMI and TG were risk factors for BMD (L1-4), besides, the decrease of BMI, ALP, and extended years of menopause were all risk factors for BMD (femoral neck).Conclusion: SOST protein expression and genetic locus rs851056, rs1230399 polymorphism are associated with bone mineral density in postmenopausal women with type 2 diabetes mellitus in Xinjiang.Keywords: SOST gene polymorphism, gene mutation, type 2 diabetes mellitus, osteoporosis, bone mineral density, SOST proteinLi JRen YLi SLi JDove Medical Pressarticlesost gene polymorphismgene mutationtype 2 diabetes mellitusosteoporosisbone mineral densitysost proteinSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4443-4450 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sost gene polymorphism gene mutation type 2 diabetes mellitus osteoporosis bone mineral density sost protein Specialties of internal medicine RC581-951
spellingShingle	sost gene polymorphism gene mutation type 2 diabetes mellitus osteoporosis bone mineral density sost protein Specialties of internal medicine RC581-951 Li J Ren Y Li S Li J Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang
description	Jun Li,1,&ast; YanXia Ren,1,&ast; SiYuan Li,2 JiaJia Li3 1Endocrinology and Metabolism Department, First Affiliated Hosptital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Shihezi University School of Medicine, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 3Endocrinology and Metabolism Department, Second People’s Hospital of Nanyang, Nanyang, Henan Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Li Email xjlijun@163.comBackground: The Wnt signaling pathway plays a valuable role in bone metabolism. SOST is a major inhibitor of the Wnt signaling pathway. The expression of SOST and genetic polymorphism might be associated with bone mineral density in postmenopausal women with type 2 diabetes mellitus (T2DM).Objective: This study aims to explore whether SOST protein expression and genetic locus rs851056, rs1230399 polymorphism is associated with bone mineral density in postmenopausal women with T2DM in Xinjiang.Methods: A total of 136 Xinjiang postmenopausal women were divided into four groups: A (-/-), B (±), C (-/+), and D (+/+) by assessing their OGTT and bone mass. Genetic polymorphisms were determined using the mass ARRAY mass spectrometer.Results: 1) Genotypes and allele frequencies at rs851056 were statistically significant differences in groups B and D patients compared to group A, respectively. 2) Individuals carrying the GG genotype had lower HDL, Ca, and ALP as compared to those carrying the GC/CC genotypes in group C. In contrast, individuals carrying the GG genotype had higher BMD (L1-4) as compared to those carrying the GC/CC genotypes in group D. 3) SOST protein expression levels were higher in groups C and D than in group A. 4). BMD (L1-4) was negatively correlated with SOST protein. 5) Multiple linear regression analysis for BMD-dependent variables showed that the decrease of BMI and TG were risk factors for BMD (L1-4), besides, the decrease of BMI, ALP, and extended years of menopause were all risk factors for BMD (femoral neck).Conclusion: SOST protein expression and genetic locus rs851056, rs1230399 polymorphism are associated with bone mineral density in postmenopausal women with type 2 diabetes mellitus in Xinjiang.Keywords: SOST gene polymorphism, gene mutation, type 2 diabetes mellitus, osteoporosis, bone mineral density, SOST protein
format	article
author	Li J Ren Y Li S Li J
author_facet	Li J Ren Y Li S Li J
author_sort	Li J
title	Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang
title_short	Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang
title_full	Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang
title_fullStr	Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang
title_full_unstemmed	Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang
title_sort	relationship between sclerostin (sost) expression and genetic loci rs851056, rs1230399 polymorphisms and bone mineral density in postmenopausal women with type 2 diabetes in xinjiang
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e4e1fe88b8ad4713816b644607662a6c
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_version_	1718379140906745856

Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang

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