Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies

Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.

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Autores principales:	Cheng Zhu, Elena Dukhovlinova, Olivia Council, Lihua Ping, Edgar M. Faison, Shamit S. Prabhu, E. Lake Potter, Stephen L. Upton, Guowei Yin, James M. Fay, Laura P. Kincer, Ean Spielvogel, Sharon L. Campbell, S. Rahima Benhabbour, Hengming Ke, Ronald Swanstrom, Nikolay V. Dokholyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4e26a3dfbec4915bf069d55e9f14cb0
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spelling	oai:doaj.org-article:e4e26a3dfbec4915bf069d55e9f14cb02021-12-02T17:31:53ZRationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies10.1038/s41467-019-08876-w2041-1723https://doaj.org/article/e4e26a3dfbec4915bf069d55e9f14cb02019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08876-whttps://doaj.org/toc/2041-1723Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.Cheng ZhuElena DukhovlinovaOlivia CouncilLihua PingEdgar M. FaisonShamit S. PrabhuE. Lake PotterStephen L. UptonGuowei YinJames M. FayLaura P. KincerEan SpielvogelSharon L. CampbellS. Rahima BenhabbourHengming KeRonald SwanstromNikolay V. DokholyanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng Zhu Elena Dukhovlinova Olivia Council Lihua Ping Edgar M. Faison Shamit S. Prabhu E. Lake Potter Stephen L. Upton Guowei Yin James M. Fay Laura P. Kincer Ean Spielvogel Sharon L. Campbell S. Rahima Benhabbour Hengming Ke Ronald Swanstrom Nikolay V. Dokholyan Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
description	Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.
format	article
author	Cheng Zhu Elena Dukhovlinova Olivia Council Lihua Ping Edgar M. Faison Shamit S. Prabhu E. Lake Potter Stephen L. Upton Guowei Yin James M. Fay Laura P. Kincer Ean Spielvogel Sharon L. Campbell S. Rahima Benhabbour Hengming Ke Ronald Swanstrom Nikolay V. Dokholyan
author_facet	Cheng Zhu Elena Dukhovlinova Olivia Council Lihua Ping Edgar M. Faison Shamit S. Prabhu E. Lake Potter Stephen L. Upton Guowei Yin James M. Fay Laura P. Kincer Ean Spielvogel Sharon L. Campbell S. Rahima Benhabbour Hengming Ke Ronald Swanstrom Nikolay V. Dokholyan
author_sort	Cheng Zhu
title	Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
title_short	Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
title_full	Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
title_fullStr	Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
title_full_unstemmed	Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
title_sort	rationally designed carbohydrate-occluded epitopes elicit hiv-1 env-specific antibodies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4e26a3dfbec4915bf069d55e9f14cb0
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Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies

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