Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate

Lysine degradation and the role of the metabolites glutarate and L-2-hydroxyglutarate have remained elusive in many organisms including Escherichia coli. Here authors present a pathway for catabolism of lysine to succinate in E. coli involving glutarate and L-2-hydroxyglutarate as intermediates.

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Autores principales:	Sebastian Knorr, Malte Sinn, Dmitry Galetskiy, Rhys M. Williams, Changhao Wang, Nicolai Müller, Olga Mayans, David Schleheck, Jörg S. Hartig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4e3b0c443c147f993908177af49c611
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spelling	oai:doaj.org-article:e4e3b0c443c147f993908177af49c6112021-12-02T15:34:25ZWidespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate10.1038/s41467-018-07563-62041-1723https://doaj.org/article/e4e3b0c443c147f993908177af49c6112018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07563-6https://doaj.org/toc/2041-1723Lysine degradation and the role of the metabolites glutarate and L-2-hydroxyglutarate have remained elusive in many organisms including Escherichia coli. Here authors present a pathway for catabolism of lysine to succinate in E. coli involving glutarate and L-2-hydroxyglutarate as intermediates.Sebastian KnorrMalte SinnDmitry GaletskiyRhys M. WilliamsChanghao WangNicolai MüllerOlga MayansDavid SchleheckJörg S. HartigNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian Knorr Malte Sinn Dmitry Galetskiy Rhys M. Williams Changhao Wang Nicolai Müller Olga Mayans David Schleheck Jörg S. Hartig Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
description	Lysine degradation and the role of the metabolites glutarate and L-2-hydroxyglutarate have remained elusive in many organisms including Escherichia coli. Here authors present a pathway for catabolism of lysine to succinate in E. coli involving glutarate and L-2-hydroxyglutarate as intermediates.
format	article
author	Sebastian Knorr Malte Sinn Dmitry Galetskiy Rhys M. Williams Changhao Wang Nicolai Müller Olga Mayans David Schleheck Jörg S. Hartig
author_facet	Sebastian Knorr Malte Sinn Dmitry Galetskiy Rhys M. Williams Changhao Wang Nicolai Müller Olga Mayans David Schleheck Jörg S. Hartig
author_sort	Sebastian Knorr
title	Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
title_short	Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
title_full	Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
title_fullStr	Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
title_full_unstemmed	Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
title_sort	widespread bacterial lysine degradation proceeding via glutarate and l-2-hydroxyglutarate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e4e3b0c443c147f993908177af49c611
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Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate

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