Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms. Here the authors show that Plk4 undergoes phase separation into an assembling body through autophos...

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Autores principales:	Jung-Eun Park, Liang Zhang, Jeong Kyu Bang, Thorkell Andresson, Frank DiMaio, Kyung S. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4e72fc607fd4764b8a9a51e47292114
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spelling	oai:doaj.org-article:e4e72fc607fd4764b8a9a51e472921142021-12-02T15:36:19ZPhase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis10.1038/s41467-019-12619-22041-1723https://doaj.org/article/e4e72fc607fd4764b8a9a51e472921142019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12619-2https://doaj.org/toc/2041-1723Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms. Here the authors show that Plk4 undergoes phase separation into an assembling body through autophosphorylation which drives centriole biogenesis.Jung-Eun ParkLiang ZhangJeong Kyu BangThorkell AndressonFrank DiMaioKyung S. LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Eun Park Liang Zhang Jeong Kyu Bang Thorkell Andresson Frank DiMaio Kyung S. Lee Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
description	Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms. Here the authors show that Plk4 undergoes phase separation into an assembling body through autophosphorylation which drives centriole biogenesis.
format	article
author	Jung-Eun Park Liang Zhang Jeong Kyu Bang Thorkell Andresson Frank DiMaio Kyung S. Lee
author_facet	Jung-Eun Park Liang Zhang Jeong Kyu Bang Thorkell Andresson Frank DiMaio Kyung S. Lee
author_sort	Jung-Eun Park
title	Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
title_short	Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
title_full	Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
title_fullStr	Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
title_full_unstemmed	Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
title_sort	phase separation of polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4e72fc607fd4764b8a9a51e47292114
work_keys_str_mv	AT jungeunpark phaseseparationofpololikekinase4byautoactivationandclusteringdrivescentriolebiogenesis AT liangzhang phaseseparationofpololikekinase4byautoactivationandclusteringdrivescentriolebiogenesis AT jeongkyubang phaseseparationofpololikekinase4byautoactivationandclusteringdrivescentriolebiogenesis AT thorkellandresson phaseseparationofpololikekinase4byautoactivationandclusteringdrivescentriolebiogenesis AT frankdimaio phaseseparationofpololikekinase4byautoactivationandclusteringdrivescentriolebiogenesis AT kyungslee phaseseparationofpololikekinase4byautoactivationandclusteringdrivescentriolebiogenesis
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Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

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